Evidence map›Paper›PMID 41016809›Full record

ReviewJournal of clinical and experimental hematopathology : JCEH2025

Bruton tyrosine kinase inhibitor in non-IgM lymphoplasmacytic lymphoma: a case report and literature review.

Kenichi Ito, Kazuhiko Hirano, Naohiro Sekiguchi

Abstract readCase ReportsReview
In one paragraph

Review in Journal of clinical and experimental hematopathology : JCEH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kenichi ItoHematology Division, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
Kazuhiko HiranoLaboratory and Pathology Division, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
Naohiro SekiguchiHematology Division, National Hospital Organization Disaster Medical Center, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-Waldenström macroglobulinemia (non-WM) lymphoplasmacytic lymphoma (LPL) is a rare subtype with limited clinical evidence and no confirmed treatment guidelines. Bruton tyrosine kinase (BTK) inhibitors represent one of the mainstay therapies in WM, but their role in non-WM LPL remains unclear. We report a case of IgG-type non-WM LPL successfully treated with a second-generation BTK inhibitor, tirabrutinib. The patient demonstrated a rapid decline in M-protein and improvement in anemia, with a durable partial response. This case adds to the limited literature supporting BTK inhibitor use in non-WM LPL and highlights the need for further studies to define optimal treatment strategies.

Indexed as

Agammaglobulinaemia Tyrosine KinaseImidazolesProtein Kinase InhibitorsPyrimidinesWaldenstrom MacroglobulinemiaAgedFemaleHumansTyrosine Kinase InhibitorsAgammaglobulinaemia Tyrosine KinaseBTK protein, humanImidazolesProtein Kinase InhibitorsPyrimidinestirabrutinibTyrosine Kinase InhibitorsBruton tyrosine kinase inhibitorMYD88 L265Pnon-IgM lymphoplasmacytic lymphomatirabrutinibWaldenström macroglobulinemia

Identifiers

PMID41016809
PMCPMC12598723

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.