SynthesisInternational journal of epidemiology2025
Body mass index and gastric cancer risk: results from the Stomach Cancer Pooling Project Consortium.
Synthesis in International journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Metabolic Syndrome, Component Burden, and Incident Gastric Cancer Risk: A Prospective Cohort Study in the UK Biobank.Cancer research communications · 2026Article
- Obesity and Cancer: Mechanisms, Epidemiological Evidence, and Potential Risk Reduction.Journal of obesity & metabolic syndrome · 2026Review
- Population ageing and gastric cancer mortality burden in China, 2008-2021: a nationwide analysis with projections to 2036.Frontiers in public health · 2026Article
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Authors and funding
26 authors.
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Abstract
backgroundBody mass index (BMI) has been associated with gastric cancer (GC), though results are conflicting regarding the GC subsites of cardia and non-cardia. This study aims to evaluate the associations between BMI and GC risk, focusing on these distinct anatomical subsites.
methodsWe pooled data from seven case-control studies from the Stomach Cancer Pooling (StoP) Project. Pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of GC risk across BMI categories (normal weight, overweight, obesity) were calculated by pooling study-specific ORs through random-effects meta-analytic models. The dose-response relationship between BMI and the risk of GC cancer was assessed by using a one-stage mixed-effects logistic regression model. Results were stratified according to cardia and non-cardia GC.
resultsThe analysis comprised 1478 GC cases, including 511 cardia and 967 non-cardia cases, and 6671 controls. There was an increased risk of cardia GC among obese patients (OR 1.57, 95% CI 1.20-2.06), while no association was found for non-cardia GC (OR 0.82, 95% CI 0.66-1.01). Restricting the analysis to population-based studies, the association for cardia GC became stronger for obese (OR 1.65, 95% CI 1.09-2.48) and overweight (OR 1.62, 95% CI 1.10-2.39) patients. The dose-response meta-analysis showed an increased risk of cardia GC with increasing BMI values, ranging from a null effect at a BMI of 21.75 to an OR of 2.06 (95% CI 1.22-3.48) for a BMI of ≥40.
conclusionOur results indicate an association between higher BMI categories and the risk of cardia GC, whereas no association was found with non-cardia GC.
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