Evidence map›Paper›PMID 41016350›Full record

ArticleBiomaterials2026

Intracortical microstimulation induces rapid microglia process convergence.

Nathaniel P Williams, Anna M Kelly, X Sally Zheng, Alberto L Vazquez, X Tracy Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nathaniel P WilliamsDepartment of Bioengineering, University of Pittsburgh, United States; Center for Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, United States.
Anna M KellyDepartment of Bioengineering, University of Pittsburgh, United States.
X Sally ZhengDepartment of Bioengineering, University of Pittsburgh, United States.
Alberto L VazquezCenter for Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, United States; Department of Radiology, University of Pittsburgh, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, United States.
X Tracy CuiDepartment of Bioengineering, University of Pittsburgh, United States; Center for Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, United States. Electronic address: xic11@pitt.edu.

Funding

Efficiency and Safety of Microstimulation Via Different Electrode MaterialsR01NS110564 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2024
$3.1M
Inhibitory Neuron Sub-populations and Their Influence on Hemodynamic ImagingR01NS117515 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAZQUEZ, ALBERTO L · 2021 to 2025
$2.6M
Nanoparticle Coated Microelectrode Arrays for Electrochemically Controlled Gene Editing at the Electrode SiteF32MH132145 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILLIAMS, NATHANIEL P · 2023 to 2025
$250k
NIMH NIH HHS F32 MH132145NINDS NIH HHS R01 NS110564NINDS NIH HHS R01 NS117515
6 · The paper itself

Abstract

Intracortical microstimulation (ICMS) has the potential to restore vision and hearing by stimulating relevant cortical regions in both animals and humans, offering significant clinical promise for sensory restoration. While the neuronal response to ICMS has been extensively studied at the cellular level through electrophysiology and two-photon (2P) imaging, the response of non-neuronal cells, particularly microglia, as well as the effects on blood-brain barrier (BBB) integrity remain poorly understood. In this study, we applied ICMS under 2P imaging in dual-reporter mice, with green fluorescent protein labeling microglia and a red fluorescent Ca

Indexed as

Electric StimulationMicrogliaAnimalsBlood-Brain BarrierGreen Fluorescent ProteinsMaleMiceMice, Inbred C57BLNeuronsGreen Fluorescent Proteins

Identifiers

PMID41016350
PMCPMC13284600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.