ReviewCurrent opinion in microbiology2025
The role of mobile genetic elements in adaptation of the microbiota to the dynamic human gut ecosystem.
Review in Current opinion in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Perturbations shift the composition of bacterial DNA carried by virus-like particles in the murine gut microbiome.bioRxiv : the preprint server for biology · 2026Article
- Natural transformation drives large-scale genome mosaicism in human gut bifidobacteria.The ISME journal · 2026Article
- High-fat diet induces an adaptive dysbiosis in the gut microbiota, associated with oxidative stress and the gut resistome profile in a rat model.Frontiers in microbiology · 2026Article
- Genomic diversity and functional adaptation ofFrontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The human intestinal microbiota is a dynamic ecosystem shaped by extensive horizontal gene transfer, particularly in individuals from industrialized populations. In this review, we discuss recent advances in our understanding of how mobile genetic elements (MGEs) contribute to microbial ecology and evolution in this diverse community, focusing on MGEs carrying fitness-conferring genes. Bacteroidales species can colonize individuals for decades and serve as major hubs for MGE exchange. Most MGEs are highly variable across individuals and geographies. Occasionally, conserved MGEs can spread across geography and lifestyles. Functional characterizations of MGEs reveal their roles in antibiotic resistance, interbacterial antagonism, biofilm formation, immune evasion, and nutrient acquisition, among others. Substantive progress in our understanding of MGEs in the gut microbiome offers promising avenues for therapeutic microbiome interventions. However, major challenges remain in functional prediction, host-MGE linkage, and experimental characterization.
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