ArticleCell reports2025
DNA damage checkpoints balance a tradeoff between diploid- and polyploid-derived arrest failures.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- ZBP1 in Neuroinflammation and Neurodegeneration: Z-Nucleic-Acid Sensing, RHIM Signalling and Therapeutic Targeting.International journal of molecular sciences · 2026Review
- Micronuclei: origins, assays, mechanisms, diseases and treatments.Signal transduction and targeted therapy · 2026Review
- Distinct p21 dynamics drive alternative routes to whole-genome duplication through a common CDK4/6-dependent polyploid G0 state.bioRxiv : the preprint server for biology · 2026Article
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3 authors.
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Abstract
The DNA damage checkpoint system ensures genomic integrity by preventing the division of damaged cells, primarily through the G1/S and G2/M checkpoints. How these checkpoints collectively minimize error remains unclear. Here, we exposed non-cancerous human cells to DNA damage and used single-cell imaging to monitor spontaneous arrest failure. Under intermediate damage, cells divided with error via two major routes: one involving mitotic skipping (extensive engagement of the G2/M checkpoint) followed by endoreplication (escape from G1/S), and the second involving escape from the G2/M checkpoint. These pathways produced distinct ploidy, nuclear morphology, and micronuclei composition. Simulations and experiments showed that strengthening one checkpoint reduced one failure mode but exacerbated the other, revealing an inherent tradeoff. Notably, our findings suggest that the DNA damage checkpoint system minimizes total error not by fully preventing either route but by permitting both to occur at sub-optimal frequencies.
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