Evidence map›Paper›PMID 41016012›Full record

ReviewBriefings in bioinformatics2025

Streamline automated biomedical discoveries with agentic bioinformatics.

Juexiao Zhou, Jindong Jiang, Zhongyi Han, Zijian Wang, Xin Gao

Abstract readReview
In one paragraph

Review in Briefings in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Juexiao ZhouSyneron Opal, 10281, Cayman Island.
Jindong JiangDepartment of Statistics, Nanjing University, Nanjing 210008, China.
Zhongyi HanComputer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia.
Zijian WangSchool of Data Science, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, P.R. China.
Xin GaoComputer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia.

Funding

Center of Excellence for Smart Health 5932Center of Excellence on Generative AI 5940Chinese University of Hong Kong, Shenzhen UDF01004172King Abdullah University of Science and Technology (KAUST) Office of Research Administration (ORA) REI/1/5234-01-01King Abdullah University of Science and Technology (KAUST) Office of Research Administration (ORA) REI/1/5289-01-01King Abdullah University of Science and Technology (KAUST) Office of Research Administration (ORA) REI/1/5404-01-01King Abdullah University of Science and Technology (KAUST) Office of Research Administration (ORA) REI/1/5414-01-01King Abdullah University of Science and Technology (KAUST) Office of Research Administration (ORA) REI/1/5992-01-01King Abdullah University of Science and Technology (KAUST) Office of Research Administration (ORA) URF/1/4663-01-01
6 · The paper itself

Abstract

The emergence of artificial intelligence agents powered by large language models marks a transformative shift in computational biology. In this new paradigm, autonomous, adaptive, and intelligent agents are deployed to tackle complex biological challenges, leading to a new research field named agentic bioinformatics. Here, we explore the core principles, evolving methodologies, and diverse applications of agentic bioinformatics. We examine how agentic bioinformatics systems work synergistically to facilitate data-driven decision-making and enable self-directed exploration of biological datasets. Furthermore, we highlight the integration of agentic frameworks in key areas such as personalized medicine, drug discovery, and synthetic biology, illustrating their potential to revolutionize healthcare and biotechnology. In addition, we address the ethical, technical, and scalability challenges associated with agentic bioinformatics, identifying key opportunities for future advancements. By emphasizing the importance of interdisciplinary collaboration and innovation, we envision agentic bioinformatics as a major force in overcoming the grand challenges of modern biology, ultimately advancing both research and clinical applications.

Indexed as

Artificial IntelligenceBiomedical ResearchComputational BiologyDrug DiscoveryHumansPrecision MedicineSynthetic BiologyAI agentsbioinformaticslarge language models

Identifiers

PMID41016012
PMCPMC12476841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.