ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025
Characterization and statistical lipid optimization of an oleaginous soil fungus, Gongronella butleri HMA-10: a promising novel source for sustainable lipid production.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oleaginous fungi, as a vital part of the microbiota in naturally diverse ecosystems, represent a reservoir for biomass-based lipid production. The challenge is the selection of promising strains with cost-effective operation for multiple applications. In the current study, 12 fungal strains were isolated and screened for their oleaginicity. All strains were fermented and accumulated over 20% lipids in their cell dry weight (CDW). After the preliminary screening, one strain was genetically identified as Gongronella butleri HMA-10 due to its maximum biomass (15.8 ± 0.8 g/L) and lipid (40.6 ± 1.7%) yields. Moreover, the HMA-10 was subjected to optimization of various parameters with the help of response surface methodology (RSM) for maximum lipid accumulation. The selected strain was fermented on fructose associated with a combination of sodium nitrite and yeast extract, exhibiting optimum nutritional conditions with a C/N ratio of (40:1). Cultivation conditions (4 days, 27.5 ℃, and pH of 7.0) resulted in the highest CDW and lipid content. Scaling up of HMA-10 in bioreactor fermentation under optimized conditions significantly induced biomass and lipid content (19.5 g/L and 53%), compared with shake flask fermentation (15.8 ± 0.8 g/L and 40.6 ± 1.7%), respectively. Fatty acid (FA) profile was confirmed by gas chromatography (GC) analysis, and the results revealed that oleic acid (OA) was the predominant (46.91%), while palmitic acid (PA), linoleic acid (LA), and γ-linolenic acid (GLA) were found in significant quantities (21.13, 9.67, and 8.06%), respectively. This study employed for the first time G. butleri HMA-10 as a promising candidate for high lipid accumulation with a potential second-generation biodiesel production in large-scale industrialization.
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