Evidence map›Paper›PMID 41015970›Full record

ArticleBiological trace element research2026

Cadmium Uptake into Rat Osteoblast UMR-106 Cells is Mediated via Multiple Pathways.

Hitomi Fujishiro, Yohei Ikeue, Seiichiro Himeno, Daigo Sumi

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hitomi FujishiroFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan. donai-do@ph.bunri-u.ac.jp.ORCID http://orcid.org/0000-0002-3000-2846
Yohei IkeueFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan.
Seiichiro HimenoFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan.
Daigo SumiFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic exposure to cadmium (Cd) has been linked to bone dysfunction, including osteomalacia and osteoporosis. Such dysfunction may result from indirect disturbances in calcium (Ca) and phosphorus metabolism due to Cd-induced nephrotoxicity, as well as from direct Cd accumulation in bone tissue. However, the mechanisms by which Cd is taken up by bone-derived cells such as osteoblasts remain unclear. Cd may enter cells via metal transporters, such as ZIP8, ZIP14, and DMT1, as well as Ca

Indexed as

CadmiumOsteoblastsAnimalsCation Transport ProteinsRatsTRPM Cation ChannelsTRPV Cation ChannelsCadmiumCation Transport ProteinsTRPM Cation ChannelsTRPV Cation ChannelsBoneCadmiumCalcium channelsOsteoblastTransporters

Identifiers

PMID41015970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.