Evidence map›Paper›PMID 41015926›Full record

ArticleElectrophoresis2025

Development of a Green Capillary Electrophoresis Method for Determining and Quality Control of Dapagliflozin: An Oral Hypoglycemic Agent.

Lívia Maronesi Bueno, Manoelly Oliveira Rocha, Amanda Mohr, Andreia Neves Fernandes, Martin Steppe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Electrophoresis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lívia Maronesi BuenoLaboratory of Pharmaceutical Quality Control, Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Manoelly Oliveira RochaLaboratory of Pharmaceutical Quality Control, Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Amanda MohrLaboratory of Pharmaceutical Quality Control, Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Andreia Neves FernandesChemistry Institute, Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Martin SteppeLaboratory of Pharmaceutical Quality Control, Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A green method by capillary electrophoresis (CE) is described for the first time for the determination of dapagliflozin (DAPA), an oral hypoglycemic drug approved for the treatment of Type 2 diabetes mellitus. The effects of different analytical conditions were evaluated, including the concentration and pH of the background electrolyte (BGE), sample injection time, applied voltage, as well as capillary temperature. The method was validated by establishing the linearity, intra- and interday precisions (relative standard deviation, RSD%), accuracy, and robustness. The analytical procedure was linear in the range of 50-175 µg mL

Indexed as

Electrophoresis, CapillaryGlucosidesAdministration, OralBenzhydryl CompoundsGreen Chemistry TechnologyHypoglycemic AgentsBenzhydryl CompoundsdapagliflozinGlucosidesHypoglycemic Agentscapillary electrophoresis | dapagliflozin | drug analyses | green method

Identifiers

PMID41015926
PMCPMC12711603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.