Evidence map›Paper›PMID 41015856›Full record

ReviewKorean journal of radiology2025

Multimodal Large Language Models in Medical Imaging: Current State and Future Directions.

Yoojin Nam, Dong Yeong Kim, Sunggu Kyung, Jinyoung Seo, Jeong Min Song, Jimin Kwon, Jihyun Kim, Wooyoung Jo, Hyungbin Park, Jimin Sung and 5 more

Abstract readReview
In one paragraph

Review in Korean journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Large language models for lumbar spondylolisthesis detection: a multi-center pilot comparative radiographic accuracy study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Yoojin Nam *Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-8565-1360
Dong Yeong Kim *Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-8548-7377
Sunggu KyungDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-7582-9484
Jinyoung SeoDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0000-6828-2508
Jeong Min SongDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0009-0335-6903
Jimin KwonDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0001-5923-9900
Jihyun KimDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0003-0378-4170
Wooyoung JoDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0000-7413-1351
Hyungbin ParkDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0007-7762-3432
Jimin SungDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0001-4053-4803
Sangah ParkDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0004-1243-2625
Heeyeon KwonDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0005-1283-6600
Taehee KwonDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0000-2707-2176
Kanghyun KimDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0009-6720-8045
Namkug KimDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-3438-2217

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multimodal large language models (MLLMs) are emerging as powerful tools in medicine, particularly in radiology, with the potential to serve as trusted artificial intelligence (AI) partners for clinicians. In radiology, these models integrate large language models (LLMs) with diverse multimodal data sources by combining clinical information and text with radiologic images of various modalities, ranging from 2D chest X-rays to 3D CT/MRI. Methods for achieving this multimodal integration are rapidly evolving, and the high performance of freely available LLMs may further accelerate MLLM development. Current applications of MLLMs now span automatic generation of preliminary radiology report, visual question answering, and interactive diagnostic support. Despite these promising capabilities, several significant challenges hinder widespread clinical adoption. MLLMs require access to large-scale, high-quality multimodal datasets, which are scarce in the medical domain. Risks of hallucinated findings, lack of transparency in decision-making processes, and high computational demands further complicate implementation. This review summarizes the current capabilities and limitations of MLLMs in medicine-particularly in radiology-and outlines key directions for future research. Critical areas include incorporating region-grounded reasoning to link model outputs to specific image regions, developing robust foundation models pre-trained on large-scale medical datasets, and establishing strategies for the safe and effective integration of MLLMs into clinical practice.

Indexed as

Artificial IntelligenceDiagnostic ImagingLanguageHumansLarge Language ModelsArtificial intelligenceLarge language modelMedical imagingMultimodal large language model

Identifiers

PMID41015856
PMCPMC12479233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.