Evidence map›Paper›PMID 41015809›Full record

Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Hewei Jiangni recipe improved the quality of life in patients with cold-heat mixed nonerosive reflux disease: a randomized, double-blinded study.

Zhang Xiaosi, Zhang Shuangyuan, Chen Hanqing, Lin Zhengdao, Xie Chune, L I Junxiang, L I Xiaohong

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhang XiaosiGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Zhang ShuangyuanGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Chen HanqingGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Lin ZhengdaoGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Xie ChuneDepartment of Spleen and Gastroenterology, Shenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China.
L I JunxiangGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
L I XiaohongGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.

Funding

Fundamental Research Funds for the Central Universities: Research on the Mechanism of Hewei Jiangni Recipe on Nonerosive Gastroesophageal Reflux Based on the Correlation Analysis of Gut Microbiota and Metabolites 2020-JYB-ZDGG-128National Natural Science Foundation of China: Exploring the Molecular Mechanism of "Hewei Jiangni Fang" Intervention in Non-erosive Reflux Disease Esophageal Hypersensitivity from the Perspective of Mas-related Gene X2/Stromal Interaction Molecule 1/Cell Adhesion Molecule 1 Pathway Regulation of Mast Cell/Dorsal Root Ganglion Communication Based on the "Xinkai-Kujiang" Method 82374401
6 · The paper itself

Abstract

objectiveTo evaluate the safety and efficacy of Hewei Jiangni recipe (, HWJNR) for treating nonerosive gastroesophageal reflux (NERD) with cold-heat complex syndrome and to clarify its mechanism based on correlation analyses of intestinal flora and metabolites.

methodsSeventy-two patients with NERD and the Traditional Chinese Medicine (TCM) syndrome of intermingled heat and cold were randomly assigned to either the TCM group or the Western Medicine group, each receiving 8 weeks of treatment. The primary outcome was the score of the gastroesophageal reflux disease questionnaire (GERD-Q). Additionally, 10 healthy individuals were recruited. Mechanistic outcomes included correlation analyses of intestinal flora and metabolites in healthy individuals and NERD participants before and after treatment.

resultsAfter 8 weeks, the effectiveness rate was 90% in the TCM group and 86.67% in the Western Medicine group (

conclusionHWJNR was clinically as effective as omeprazole and demonstrated advantages in improving quality of life.

Indexed as

Drugs, Chinese HerbalGastroesophageal RefluxAdultAgedCold TemperatureDouble-Blind MethodFemaleHot TemperatureHumansMaleMiddle AgedQuality of LifeTreatment OutcomeYoung AdultDrugs, Chinese HerbalChinese herbal medicinegut microbiotaHewei Jiangni recipenon-erosive gastroesophageal reflux diseaserandomized controlled trial

Identifiers

PMID41015809
PMCPMC12454263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.