Evidence map›Paper›PMID 41015769›Full record

ReviewGenome biology2025

Machine learning and statistical inference in microbial population genomics.

Samuel K Sheppard, Nicolas Arning, David W Eyre, Daniel J Wilson

Abstract readReview
In one paragraph

Review in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel K SheppardIneos Oxford Institute for Antimicrobial Research, Department of Biology, University of Oxford, Oxford, United Kingdom.
Nicolas ArningBig Data Institute, Oxford Population Health, University of Oxford, Oxford, United Kingdom.
David W EyreBig Data Institute, Oxford Population Health, University of Oxford, Oxford, United Kingdom.
Daniel J WilsonBig Data Institute, Oxford Population Health, University of Oxford, Oxford, United Kingdom. daniel.wilson@bdi.ox.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/M011224/1Royal Society 101237/Z/13/BUK Research and Innovation MR/L015080/1Wellcome 088786/C/09/ZWellcome 101237/Z/13/BWellcome Trust
6 · The paper itself

Abstract

The availability of large genome datasets has changed the microbiology research landscape. Analyzing such data requires computationally demanding analyses, and new approaches have come from different data analysis philosophies. Machine learning and statistical inference have overlapping knowledge discovery aims and approaches. However, machine learning focuses on optimizing prediction, whereas statistical inference focuses on understanding the processes relating variables. In this review, we outline the different aspirations, precepts, and resulting methodologies, with examples from microbial genomics. Emphasizing complementarity, we argue that the combination and synthesis of machine learning and statistics has potential for pathogen research in the big data era.

Indexed as

Genome, MicrobialGenomicsMachine LearningMicrobiotaDatasets as TopicDrug Resistance, MicrobialGenome-Wide Association StudySequence Analysis, DNAVirulence

Identifiers

PMID41015769
PMCPMC12476627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.