Evidence map›Paper›PMID 41015610›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function.

Arvie Rodriguez Abiero, Joanne M Gladding, Jacqueline A Iredale, Hannah R Drury, Elizabeth E Manning, Christopher V Dayas, Amolika Dhungana, Kiruthika Ganesan, Karly Turner, Serena Becchi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Arvie Rodriguez Abiero *School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Joanne M Gladding *School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Jacqueline A IredaleSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Hannah R DrurySchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Elizabeth E ManningSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.ORCID 0000-0002-1897-8950
Christopher V DayasSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Amolika DhunganaSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Kiruthika GanesanSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Karly TurnerSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0003-3714-5118
Serena BecchiDecision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.
Michael D KendigSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.ORCID 0000-0003-3337-6402
Christopher NolanDecision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-0621-2907
Bernard BalleineDecision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0001-8618-7950
Alessandro CastorinaSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Louise ColeSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Kelly J ClemensSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0003-2709-218X
Laura A BradfieldSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia. laura.bradfield@sydney.edu.au.ORCID 0000-0003-3921-0745

Funding

Department of Education and Training | Australian Research Council (ARC) DP200102445Department of Health | National Health and Medical Research Council (NHMRC) GNT1147207Department of Health | National Health and Medical Research Council (NHMRC) GNT2003346Department of Health | National Health and Medical Research Council (NHMRC) GNT2020768Department of Health | National Health and Medical Research Council (NHMRC) GNT2028533
6 · The paper itself

Abstract

Compulsive actions are typically thought to reflect the dominance of habits over goal-directed action. To investigate this, we mimicked the striatal neuroinflammation that is frequently exhibited in individuals with compulsive disorders in rats, by injecting the endotoxin lipopolysaccharide into the posterior dorsomedial striatum, and assessed the consequences for behavioural control. Surprisingly, this manipulation caused rats to acquire and maintain goal-directed actions under conditions that would otherwise produce habits. Immunohistochemical analyses indicated that these behaviours were a result of astrocytic proliferation. To probe this further, we chemogenetically activated the Gi-pathway in striatal astrocytes, which altered the firing properties of nearby medium spiny neurons and modulated goal-directed action control. Together, results show that striatal neuroinflammation is sufficient to bias action selection toward excessive goal-directed control via dysregulated astrocyte function. If translatable, our findings suggest that, contrary to conventional views, individuals with striatal neuroinflammation might be more prone to maladaptive goal-directed actions than habits, and future interventions should aim to restore appropriate action control.

Indexed as

AstrocytesCompulsive BehaviorCorpus StriatumGoalsNeuroinflammatory DiseasesAnimalsLipopolysaccharidesMaleRatsLipopolysaccharides

Identifiers

PMID41015610
PMCPMC12708733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.