Evidence map›Paper›PMID 41015608›Full record

SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025

Complication and revision risks of surgical treatment for proximal humerus metastases: a systematic review.

Konstantina Solou, Filippo Tamburini, Monica Cosentino, Barbara Bordini, Barbara Dozza, Davide Maria Donati, Costantino Errani

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Konstantina SolouDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Filippo TamburiniDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Monica CosentinoMedical Technology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Barbara BordiniMedical Technology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Barbara DozzaDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Davide Maria DonatiDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Costantino ErraniDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. costantino.errani@ior.it.

Funding

NextGenerationEU J53D23012420006
6 · The paper itself

Abstract

purposeSurgical treatments for proximal humerus metastasis include modular prosthesis, intramedullary nailing, plate fixation, and hemiarthroplasty. However, it is controversial which surgical treatment could offer less complications and implant failure. The purpose of our study was to report the risk of complications, reoperations and revisions in patients with proximal humerus metastasis treated with modular prosthesis, intramedullary nailing, plate fixation, or hemiarthroplasty.

methodsWe performed research in the PubMed and Scopus libraries, obtaining 2247 studies. We analyzed studies reporting the risk of complications, reoperations and removal of the implant in patients with proximal humerus metastasis treated with intramedullary nailing, plate fixation, hemiarthroplasty, or megaprosthesis.

resultsWe included 11 studies (357 patients) reporting patients treated with modular prosthesis (n = 181), intramedullary nailing (n = 101), plate fixation (n = 51) and hemiarthroplasty (n = 24). The risk of complications in patients with proximal humerus metastasis treated with modular prosthesis was 0-40%, with intramedullary nailing was 0-39%, with plate fixation was 0-67% and with hemiarthroplasty was 8%. The risk of reoperation in patients treated with modular prosthesis was between 0 and 20%, with intramedullary nailing was 0-3%, and with plate fixation was 0-33% and no patient treated with hemiarthroplasty had a reoperation. The risk of removal of the implant in patients treated with modular prosthesis and plate fixation was 0-20% and 0-33%, respectively. No patients treated with intramedullary nailing and hemiarthroplasty had a removal of the implant.

conclusionModular prosthesis, intramedullary nailing, plate fixation and hemiarthroplasty seem to have similar risk of complications, reoperation and removal of the implant. Surgeons should consider the indications of each treatment option, taking into account other factors such as the location and size of the lesion, the quality of the cortical bone and the patient's life expectancy.

Indexed as

Bone NeoplasmsHumerusPostoperative ComplicationsArthroplasty, Replacement, ShoulderBone NailsBone PlatesDevice RemovalFracture Fixation, IntramedullaryHemiarthroplastyHumansProsthesis FailureReoperationShoulder FracturesComplicationHemiarthroplastyIntramedullary nailingModular prosthesisPlate fixationProximal humerus metastasisReoperationRevisionSurgical treatment

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.