Evidence map›Paper›PMID 41015600›Full record

ReviewJournal of gastrointestinal cancer2025

Comprehensive Review of Transarterial Chemoembolization Plus Systemic Therapy in Advanced Hepatocellular Carcinoma.

Arif Akyildiz, Betul Gok Yavuz, Rashad Ismayilov, Muge Buyukaksoy, Sena Sozen, Joe Ramzi Eid, Rony Avritscher, Lee Sunyoung, Suayib Yalcin, Ahmed O Kaseb

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arif AkyildizDepartment of Medical Oncology, Hacettepe University Medical School, Ankara, Turkey.ORCID http://orcid.org/0000-0002-4452-2076
Betul Gok YavuzDepartment of Medicine, The University of Missouri, Columbia, MO, USA.ORCID http://orcid.org/0000-0003-3786-1456
Rashad IsmayilovDepartment of Medical Oncology, Baskent University Medical School, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7093-2722
Muge BuyukaksoyDepartment of Internal Medicine, Ankara Bilkent City Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-4722-5472
Sena SozenDepartment of Internal Medicine, Ankara Bilkent City Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-3539-8875
Joe Ramzi EidDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0009-0008-7691-0170
Rony AvritscherDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5122-3445
Lee SunyoungDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5954-5991
Suayib YalcinDepartment of Medical Oncology, Hacettepe University Medical School, Ankara, Turkey.ORCID http://orcid.org/0000-0001-7850-6798
Ahmed O KasebDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. akaseb@mdanderson.org.ORCID http://orcid.org/0000-0002-9491-0587

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHepatocellular carcinoma (HCC) is the most common primary liver cancer and the fifth most common cancer worldwide. For patients with unresectable, localized, intermediate-stage HCC, the standard treatment is transarterial chemoembolization (TACE).

methodsGiven the recent advances in systemic treatments for HCC with immunotherapy and targeted therapies, several studies have explored the potential benefits of combining TACE with systemic therapy, owing to the possible synergistic effects. This review analyzes recent clinical studies of patients with unresectable HCC who received TACE in combination with different classes of systemic therapies.

conclusionCollectively, these studies suggest that combining TACE with systemic therapy may enhance treatment response and improve survival outcomes.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsCombined Modality TherapyHumansTreatment OutcomeHepatocellular carcinomaICITACETKITransarterial chemoembolization

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.