Evidence map›Paper›PMID 41015564›Full record

ReviewZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

[Research progress in the role of STMN1 in tumor].

Xingxing Ma, Muzi Li, La Chen, Huijuan Mei, Ziye Rong

Abstract readReviewEnglish Abstract
In one paragraph

Review in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xingxing MaFirst School of Clinical Medicine, Anhui Medical University, Hefei 230032. 2412852241@qq.com.
Muzi LiDepartment of Immunology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China.
La ChenDepartment of Immunology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China.
Huijuan MeiDepartment of Immunology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China.
Ziye RongDepartment of Immunology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China. 2021500003@ahmu.edu.cn.

Funding

the Anhui Medical University College Students' Innovation and Entrepreneurship Program AYDDCxj2022011the "Early Exposure Research Program" of Anhui Medical University 2021-ZQKY-110This work was supported by the Natural Science Foundation of Anhui Province 2308085QH276
6 · The paper itself

Abstract

Stathmin 1 (STMN1) is a microtubule-binding cytoplasmic phosphoprotein that promotes microtubule depolymerization or inhibits microtubule assembly, thereby regulating cytoskeletal organization and cell cycle progression. STMN1 is upregulated in a variety of malignant tumors, where it drives proliferation, invasion, metastasis, and angiogenesis through classic pathways such as nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and ferroptosis. STMN1 can also modulate the function of immune cells, thereby influencing antitumor immunity. Clinical data show that its high expression correlates positively with tumor drug resistance and poor prognosis, suggesting that STMN1 has potential as a tumor biomarker and therapeutic molecular target with important clinical significance.

Indexed as

Biomarkers, TumorNeoplasmsStathminAnimalsAntineoplastic AgentsDisease-Free SurvivalDrug Resistance, NeoplasmFerroptosisGene Expression Regulation, NeoplasticHumansMAP Kinase Signaling SystemNF-kappa BPrognosisTumor EscapeUp-RegulationAntineoplastic AgentsBiomarkers, TumorNF-kappa BStathminSTMN1 protein, humanferroptosismicrotubulestathmin 1tumortumor drug resistancetumor immunity

Identifiers

PMID41015564
PMCPMC12464925

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.