Evidence map›Paper›PMID 41015558›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

[Ameliorative effects and mechanisms of an integrated endoplasmic reticulum stress inhibitor on lipopolysaccharide-induced cognitive impairment in mice].

Dandan Liu, Wenjia Liu, Lihua Xie, Xiaofan Xu, Xiaolin Zhong, Wenyu Cao, Yang Xu, Ling Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Protective effect of the endoplasmic reticulum stress inhibitor 4-phenylbutyric acid against myocardial injury in septic mice].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dandan LiuDepartment of Endocrinology and Metabolism, First Affiliated Hospital, University of South China, Hengyang 421001. 714036750@qq.com.
Wenjia LiuDepartment of Endocrinology and Metabolism, First Affiliated Hospital, University of South China, Hengyang 421001.
Lihua XieDepartment of Endocrinology and Metabolism, First Affiliated Hospital, University of South China, Hengyang 421001.
Xiaofan XuClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang 421001.
Xiaolin ZhongDepartment of Endocrinology and Metabolism, First Affiliated Hospital, University of South China, Hengyang 421001.
Wenyu CaoClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang 421001.
Yang XuInstitute of Neuroscience, Hengyang Medical School, University of South China, Hengyang 421001, China. xuyang2117@163.com.
Ling ChenDepartment of Endocrinology and Metabolism, First Affiliated Hospital, University of South China, Hengyang 421001. lingchen-cl@outlook.com.

Funding

the Natural Science Foundation of Hunan Province 2022JJ30486This work was supported by the National Natural Science Foundation 82100537
6 · The paper itself

Abstract

objectivesThe integrated endoplasmic reticulum stress inhibitor (ISRIB) is a selective inhibitor of the protein kinase R-like endoplasmic reticulum kinase (PERK) signaling pathway within endoplasmic reticulum stress (ERS) and can improve spatial and working memory in aged mice. Although ERS and oxidative stress are tightly interconnected, it remains unclear whether ISRIB alleviates cognitive impairment by restoring the balance between ERS and oxidative stress. This study aims to investigate the effects and mechanisms of ISRIB on lipopolysaccharide (LPS)-induced cognitive impairment in mice.

methodsEight-week-old male ICR mice were randomly divided into 3 groups: Normal saline (NS) group, LPS group, and ISRIB+LPS group. NS and LPS groups received daily intraperitoneal injections of normal saline for 7 days; on day 7, LPS group mice received intraperitoneal LPS (0.83 mg/kg) to establish a cognitive impairment model. ISRIB+LPS group received ISRIB (0.25 mg/kg) intraperitoneally for 7 days, with LPS injected 30 minutes after ISRIB on day 7. Cognitive ability was evaluated by the novel place recognition test (NPRT). Real-time fluorogenic quantitative PCR (RT-qPCR) was used to detect changes in nitric oxide synthase (

resultsCompared with the NS group, mice in LPS group showed a significant reduction in novel place recognition ratio, upregulation of hippocampal

conclusionsISRIB improves LPS-induced cognitive impairment in mice by restoring the oxidative/antioxidant balance in the hippocampus.

Indexed as

Cognitive DysfunctionEndoplasmic Reticulum StressGuanidinesAnimalseIF-2 KinaseHippocampusLipopolysaccharidesMaleMiceMice, Inbred ICRNitric Oxide Synthase Type IIOxidative StressSignal TransductionSuperoxide DismutaseeIF-2 KinaseGuanidinesLipopolysaccharidesNitric Oxide Synthase Type IISuperoxide Dismutasecognitive impairmentendoplasmic reticulum stresshippocampusintegrated endoplasmic reticulum stress inhibitorlipopolysaccharideoxidative stress

Identifiers

PMID41015558
PMCPMC12464928

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.