Evidence map›Paper›PMID 41015554›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

Five novel

Yanna Cao, Zhihong Deng, Guiyun He, Li Xiao, Feng Zhang, Feng Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanna CaoDepartment of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013. cnn117@163.com.
Zhihong DengDepartment of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013.
Guiyun HeDepartment of Ophthalmology, First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha 410002.
Li XiaoDepartment of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013.
Feng ZhangDepartment of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013. fengz2022@csu.edu.cn.
Feng SuDepartment of Emergency, Xiangya Hospital, Central South University, Changsha 410013, China. sufeng@csu.edu.cn.

Funding

the National Natural Science Foundation 82271057the Natural Science Foundation of Hunan Province 2023JJ30818This is an open access article under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International CC BY-NC-ND 4.0 and //creativecommons.org/licenses/by-nc-nd/4.0/
6 · The paper itself

Abstract

objectivesKeratoconus (KC) is a progressive corneal ectasia disorder, arising from a myriad of causes including genetic predispositions, environmental factors, biomechanical influences, and inflammatory reactions. This study aims to identify potential pathogenetic gene mutations in patients with sporadic KC in the Han Chinese population.

methodsTwenty-five patients with primary KC as well as 50 unrelated population-matched healthy controls, were included in this study to identify potential pathogenic gene mutations among sporadic KC patients in the Han Chinese population. Sanger sequencing and whole-exome sequencing (WES) were used to analyze mutations in the zinc finger protein 469 (

resultsFive novel heterozygous missense variants were identified in KC patients. Among them, 2 compound heterozygous variants, c.8986G>C (p. E2996Q) with c.11765A>C (p. D3922A), and c.4423C>G (p. L1475V) with c.10633G>A (p. G3545R), were determined to be possible pathogenic factors for KC.

conclusionsMutations in the

Indexed as

KeratoconusMutationMutation, MissenseTranscription FactorsAdolescentAdultCase-Control StudiesChinaEast Asian PeopleExome SequencingFemaleGenetic Predisposition to DiseaseHumansMaleTranscription FactorsZNF469 protein, humanHan Chinese populationkeratoconusmutationSanger sequencingZNF469 gene

Identifiers

PMID41015554
PMCPMC12464922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.