Evidence map›Paper›PMID 41015536›Full record

ArticleThe Journal of physiology2025

Adeno-associated virus-based rescue of Myo7a expression restores hair-cell function and improves hearing thresholds in a USH1B mouse strain.

Ana E Amariutei, Samuel Webb, Adam J Carlton, Andrew O'Connor, Anna Underhill, Jing-Yi Jeng, Sarah A Hool, Alice Zanella, Matthew Hool, Marie-José Lecomte and 3 more

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Limited Potential to Reverse Deafness Caused by Mutation of Myo7a.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Article
  2. Article
  3. Hair cell loss - cause or consequence of hearing loss?Frontiers in cell and developmental biology · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ana E AmariuteiSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0000-0001-5803-1166
Samuel WebbSchool of Biosciences, University of Sheffield, Sheffield, UK.
Adam J CarltonSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0000-0002-1054-3901
Andrew O'ConnorSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0009-0001-0693-6251
Anna UnderhillSchool of Biosciences, University of Sheffield, Sheffield, UK.
Jing-Yi JengSchool of Biosciences, University of Sheffield, Sheffield, UK.
Sarah A HoolSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0009-0000-9896-4534
Alice ZanellaSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0009-0003-2585-2744
Matthew HoolSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0009-0005-2172-1725
Marie-José LecomteUniversité Paris Cité, Institut Pasteur, AP-HP, INSERM, CNRS, Fondation Pour l'Audition, Institut de l'Audition, IHU reConnect, Paris, France.ORCID 0000-0001-5097-6798
Stuart L JohnsonSchool of Biosciences, University of Sheffield, Sheffield, UK.
Saaid SafieddineUniversité Paris Cité, Institut Pasteur, AP-HP, INSERM, CNRS, Fondation Pour l'Audition, Institut de l'Audition, IHU reConnect, Paris, France.
Walter MarcottiSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8770-7628

Funding

Fondation pour l'Audition FPA IDA08French National Research Agency ANR-18-RHUS-0007Royal National Institute for Deaf People (RNID) S56UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X000567/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/Z514743/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/Z516685/1Wellcome Trust 224326Wellcome Trust 300350Wellcome Trust (WT) 224326/Z/21/ZWellcome Trust (WT) 300350/Z/23/Z
6 · The paper itself

Abstract

Mutations in MYO7A, the gene encoding the unconventional myosin 7a, cause hereditary deafness in mice and humans. In the cochlea, MYO7A is present in the sensory hair cells from embryonic stages of development, and plays a critical role in the development and maintenance of the mechanosensitive hair bundles composed of actin-rich stereocilia. Shaker-1 mutant mice (Myo7a

Indexed as

Auditory ThresholdDependovirusGenetic TherapyHair Cells, AuditoryHair Cells, Auditory, InnerMyosinsUsher SyndromesAnimalsHair Cells, Auditory, OuterMiceMyosin VIIaStereociliaMyo7a protein, mouseMyosinsMyosin VIIacochleadeafnessgene‐based therapyhair cellion channelsmechanoelectrical transductionmyosin motorribbon synapses

Identifiers

PMID41015536
PMCPMC7618387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.