ArticleJournal of neurophysiology2025
Noninvasive spatiotemporal spinal neuromodulation targeting dorsal roots improves paretic leg motor control during walking in persons with stroke.
Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Individuals post-stroke demonstrate impaired motor control and muscle weakness in the paretic leg interfering their mobility. We aimed to determine whether applying spatiotemporally controlled transcutaneous spinal cord stimulation (tSCS), when combined with constraint force-induced forced use (CIFU), enhances paretic leg motor control during walking in individuals post-stroke. Thirteen individuals with stroke (age: 64.2 ± 7.1 yr old; time post-stroke: 14.1 ± 6.1 yr) were tested in a crossover design under two conditions: active versus sham tSCS during CIFU treadmill walking (tSCS + CIFU vs. sham + CIFU). In both conditions, CIFU treadmill walking was performed with a constraint force applied to the nonparetic leg during the swing phase of gait. For the active condition, tSCS was delivered at L4 during the swing phase (80 Hz) and at S1 during the stance phase (30 Hz) of the paretic leg, filled with a carrier frequency of 9.5 kHz. Spatiotemporal gait parameters, muscle activity, and propulsive force were assessed. Participants showed greater increases in paretic step length and step height in the tSCS + CIFU condition compared with the sham + CIFU condition, whereas showed prolonged paretic stance time in both conditions. The tSCS + CIFU condition also showed significantly less foot path variability of the paretic leg compared with sham + CIFU. Muscle synergy analysis revealed increased muscle weightings in plantarflexion, dorsiflexion, and hip/knee extension synergies of the paretic leg in both conditions. Propulsive force of the paretic leg showed no change in both conditions. In conclusion, applying spatiotemporally controlled tSCS during CIFU treadmill walking may enhance paretic leg motor control in individuals post-stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.