Evidence map›Paper›PMID 41015430›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Sex differences in renal acid-base regulation.

Jessica A Dominguez Rieg, Louise Nyrup Odgaard, Jianxiang Xue, Jennifer Nogueira Coelho, Autumn N Harris, Linto Thomas, Robert A Fenton, Timo Rieg

Abstract readComparative Study
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Sex differences in renal acid-base regulation.Current opinion in nephrology and hypertension · 2026
    Review
  3. Article
  4. Article
  5. Unusual case ofFrontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica A Dominguez RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0001-6190-7464
Louise Nyrup OdgaardDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0009-0006-3071-7098
Jianxiang XueDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, New Mexico, United States.ORCID 0000-0001-8847-0581
Jennifer Nogueira CoelhoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0009-0007-1643-6772
Autumn N HarrisDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States.ORCID 0000-0002-2329-3905
Linto ThomasDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0003-3344-1307
Robert A FentonDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, New Mexico, United States.ORCID 0000-0003-1623-199X
Timo RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0001-6082-662X

Funding

American Heart Association (AHA) 24CDA1271666BLRD VA I01 BX004968Fondation Leducq (Leducq Foundation) 17CVD05Independent Research Fund Denmark 0134-00018BNovo Nordisk Fonden (NNF) NNF21OC0067647U.S. Department of Veterans Affairs (VA) IBX004968A
6 · The paper itself

Abstract

Transport across cells of the renal tubule differs between females and males, possibly as a consequence of varying abundance of transport proteins along the nephron. We hypothesized that sex-specific differences in the physiological responses and in transport protein abundances exist in the context of acid-base challenges. We used female and male C57Bl/6J mice and challenged them with acid (NH

Indexed as

Acid-Base EquilibriumAcid-Base ImbalanceKidneyAnimalsFemaleHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLSex CharacteristicsSex FactorsSodium BicarbonateSolute Carrier Family 12, Member 1Slc12a1 protein, mouseSodium BicarbonateSolute Carrier Family 12, Member 1acid-basehomeostasissex differences

Identifiers

PMID41015430
PMCPMC12667237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.