ArticleJournal of neuroscience methods2025
BrainTRACE (Brain Tumor Registration and Cortical Electrocorticography): A novel tool for localizing electrocorticography electrodes in patients with brain tumors.
Article in Journal of neuroscience methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- A Low-Cost Modular Multi-Region Electrode for Distributed Network Recording and Brain State Decoding.Brain sciences · 2026Article
- A modular and flexible pipeline for intraoperative electrode reconstruction and localization in patients with brain lesions.Frontiers in neural circuits · 2026Article
- Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation.bioRxiv : the preprint server for biology · 2025Article
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Abstract
backgroundIntraoperative electrocorticography (ECoG) plays a critical role in clinical care and neuroscience research, enabling precise mapping of human cortex. However, localizing subdural electrodes in patients with brain tumors presents unique challenges due to altered neuroanatomy and the impracticality of acquiring extraoperative imaging. NEW
methodTo address these gaps, we developed BrainTRACE, a novel MATLAB tool that combines MRI, cortical vascular reconstructions, and intraoperative photography for accurate subdural electrode grid placement. Preoperative MRI, cortical photography, and subdural electrode array data were recorded from patients with diffuse glioma and brain metastasis. BrainTRACE generated 3D cortical surfaces, integrated vascular reconstructions, and enabled precise placement of electrode grids. Each electrode was placed based on cortical anatomy and vascular landmarks informed by intraoperative photographs.
resultsExpert users achieved high consistency and accuracy, with an intraclass correlation coefficient (ICC) of 0.934 and a mean deviation of 4.3 mm from consensus placements. Novice users demonstrated lower reliability and greater variability, highlighting the non-trivial nature of intraoperative ECoG localization, which requires neuroanatomical expertise. COMPARISON WITH EXISTING
methodsTo our knowledge, BrainTRACE is the first freely available tool that enables photograph-guided ECoG localization using cortical surface reconstructions and vascular anatomy without relying on post-operative imaging.
conclusionsBrainTRACE enables accurate localization of intraoperative ECoG electrodes in brain tumor patients. By integrating anatomical images, intraoperative photographs, and vascular mapping, the tool addresses challenges posed by tumor-induced artifacts. BrainTRACE provides a freely available practical tool for neurosurgical and neuroscience applications, including brain malignancy, epilepsy, and deep brain stimulation.
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