Evidence map›Paper›PMID 41015389›Full record

ArticleNeuropharmacology2025

Reward-associated cues reduce H-current amplitude in midbrain dopamine neurons.

Cristhian G Calo-Guadalupe, Karl Y Bosque-Cordero, Joseph Capella-Muñiz, Daisy Consuegra-García, Rafael Vazquez-Torres, Omaris Vélez-Acevedo, Keven Laboy-Juarez, Priscila Sanabria, Carlos A Jimenez-Rivera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristhian G Calo-GuadalupePhysiology Department, University of Puerto Rico Medical Sciences Campus, PR, Puerto Rico.
Karl Y Bosque-CorderoCenter for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Joseph Capella-MuñizPhysiology Department, University of Puerto Rico Medical Sciences Campus, PR, Puerto Rico.
Daisy Consuegra-GarcíaPhysiology Department, University of Puerto Rico Medical Sciences Campus, PR, Puerto Rico.
Rafael Vazquez-TorresDepartment of Neural Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Omaris Vélez-AcevedoNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Keven Laboy-JuarezMolecular Science Research Center, University of Puerto Rico, PR, Puerto Rico.
Priscila SanabriaUniversidad Central del Caribe, Bayamón, P.R, Puerto Rico.
Carlos A Jimenez-RiveraPhysiology Department, University of Puerto Rico Medical Sciences Campus, PR, Puerto Rico; Molecular Science Research Center, University of Puerto Rico, PR, Puerto Rico. Electronic address: carlos.jimenez8@upr.edu.

Funding

Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
Neuroscience Research Opportunities to Increase Diversity (NeuroID)R25NS080687 · NINDS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI GARCIA-ARRARAS, JOSE E, MALDONADO-VLAAR, CARMEN SARA · 2012 to 2024
$5.3M
Elucidating Ih Biophysical Epigenetic Modifications in VTA Dopaminergic Neurons after Contingent and Non-Contingent Cocaine AdministrationR16GM145475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI JIMENEZ-RIVERA, CARLOS A · 2022 to 2025
$884k
NIGMS NIH HHS R16 GM145475NIGMS NIH HHS R25 GM061151NIGMS NIH HHS R25 GM061838NINDS NIH HHS R25 NS080687
6 · The paper itself

Abstract

Cocaine is a psychoactive substance that targets brain regions involved in motivation and reward learning. Lateral ventral tegmental area (VTA) dopamine (DA) neurons play a critical role in these processes, yet their intrinsic modulations during drug and non-drug self-administration or reward-associated cue learning remain poorly understood. This study employed an Intermittent Access (IntA) cocaine model, both contingent and non-contingent, to examine how reward delivery and associated cues modulate the hyperpolarization-activated cyclic nucleotide-gated (HCN) current (I

Indexed as

CuesDopaminergic NeuronsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMesencephalonRewardVentral Tegmental AreaAnimalsCocaineDopamine Uptake InhibitorsMaleRatsRats, Sprague-DawleySelf AdministrationCocaineDopamine Uptake InhibitorsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAssociative learningCocaineElectrophysiologyI(h) currentNon-drug rewardRatsSubstance abuse disorderSynaptic integrationVentral tegmental area

Identifiers

PMID41015389
PMCPMC12571193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.