Evidence map›Paper›PMID 41015326›Full record

ArticlePharmacological research2025

Imaging of mitochondrial matrix pH dynamics reveals a functional interaction between the ADP/ATP carrier and ATP synthase to regulate H

Bernard Ribalet, Scott John, Madeleine G Milner, Leia Salongo, Ambre M Bertholet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bernard RibaletDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States. Electronic address: bribalet@mednet.ucla.edu.
Scott JohnDepartment of Medicine (Division of Cardiology), David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Madeleine G MilnerDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Leia SalongoDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Ambre M BertholetDepartment of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States. Electronic address: abertholet@mednet.ucla.edu.

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Mechanisms of regulation of mitochondrial H+ leak and thermogenesisR35GM143097 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERTHOLET, AMBRE MARGUERITE SOLANGE · 2021 to 2025
$1.9M
NIDDK NIH HHS P30 DK063491NIGMS NIH HHS R35 GM143097
6 · The paper itself

Abstract

In mitochondria, the energy derived from the proton gradient across the mitochondrial inner membrane (IMM) is converted into ATP and heat. For these conversions to occur, H

Indexed as

MitochondriaMitochondrial ADP, ATP TranslocasesMitochondrial Proton-Translocating ATPasesAnimalsCell LineHydrogen-Ion ConcentrationMiceMitochondrial MembranesMyoblastsMitochondrial ADP, ATP TranslocasesMitochondrial Proton-Translocating ATPasesADP/ATP carrierATP synthaseBAM15Electron transport chainFCCPMitochondriaPH sensorProton transportUncoupling protein

Identifiers

PMID41015326
PMCPMC12908653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.