Trial reportChest2026
Specialist Dietary Intervention in Patients With Fibrotic Interstitial Lung Disease Experiencing Unintentional Weight Loss: A Pilot Randomized Controlled Trial.
Trial report in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06016959 (Specialist Dietetic Intervention in Malnourished Patients with Fibrotic ILD), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Specialist Dietetic Intervention in Malnourished Patients with Fibrotic ILD: a Randomised Controlled Pilot Trial
Who cites it
2 citing papers in PubMed.
- Review of the Impact of Weight Loss and Body Mass Index in Clinical Trials of Nintedanib in Interstitial Lung Disease.Advances in therapy · 2026Article
- Geriatric nutritional risk index in antifibrotic therapy can predict tolerability and mortality risk.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWeight loss in patients with fibrotic interstitial lung disease (F-ILD) is associated with poor prognosis, yet the impact of dietary input is unknown. RESEARCH QUESTION: What is the feasibility of a randomized controlled trial of specialist dietary intervention in F-ILD? STUDY DESIGN AND
methodsPatients with F-ILD experiencing low weight or weight loss were randomized 1:1 to either a 12-week specialist dietary intervention or a dietary information sheet by computer-generated sequence using random block design with stratification by antifibrotic drugs. The primary outcome was feasibility of recruitment, randomization, and retention. A key predefined exploratory outcome was weight change from baseline.
resultsOf 128 screened patients, 40 patients (31%) were randomized, 19 to diet and 21 to control arm. The target number of patients was reached within 7 months, suggesting feasibility of a larger trial. All randomized patients completed the study. In the diet arm, 8 of 19 (42%) vs 1 of 21 (4.8%) participants in the control arm gained ≥ 1 kg at 12 weeks (OR, 14.2; 95% CI, 1.4-141.8; P = .02). Analysis of the exploratory outcome of weight change revealed that after a 4-week lag, the estimated rate of weight change between 4 and 12 weeks was -0.25 kg/month (95% CI, -0.61 to 0.12) in the control and +0.40 kg/month (95% CI, 0.02 to 0.78) in the diet group, with a difference of +0.65 kg/month (95% CI, 0.15 to 1.14) in favor of the diet group (P = .01).
interpretationBased on the encouraging results of this pilot trial of dietary intervention in F-ILD, a definitive multicenter randomized controlled trial is warranted. CLINICAL
trial registrationClinicalTrials.gov; No.: NCT06016959; URL: www. CLINICALTRIALS: gov).
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