Evidence map›Paper›PMID 41015192›Full record

ArticleThe American journal of clinical nutrition2025

Gut microbiota-derived proinflammatory biomarkers and risk of coronary heart disease: a prospective study among United States males and females.

Siyue Wang, Rikuta Hamaya, Μolin Wang, Kenneth J Mukamal, Marta Epeldegui, Qibin Qi, Qi Sun, Eric B Rimm

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PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siyue WangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Rikuta HamayaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Μolin WangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Kenneth J MukamalDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Marta EpeldeguiUCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, United States; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States.
Qi SunDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Joslin Diabetes Center, Boston, MA, United States.
Eric B RimmDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: erimm@hsph.harvard.edu.

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Risk Factors for Ischemic Stroke in WomenR01HL088521 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REXRODE, KATHRYN M · 2008 to 2025
$9.9M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0M
Metabolomics Core for the Dietary Biomarkers Development Center at Harvard UniversityU2CDK129670 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI SUN, QI · 2021 to 2025
$7.0M
NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA067262NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL060712NHLBI NIH HHS R01 HL088521NHLBI NIH HHS U01 HL145386NIDDK NIH HHS R01 DK119268NIDDK NIH HHS R01 DK120870NIDDK NIH HHS R01 DK126698NIDDK NIH HHS U2C DK129670NIEHS NIH HHS R01 ES022981
6 · The paper itself

Abstract

backgroundExposure to lipopolysaccharide (LPS), a potent proinflammatory glycolipid derived from gut microbiota, may be linked to the development of coronary heart disease (CHD). However, evidence from human studies is limited.

objectivesWe aimed to investigate prospective relationships between 2 plasma biomarkers of LPS exposures-LPS-binding protein (LBP) and soluble cluster of differentiation 14 (sCD14)-in relation to incident CHD among United States males and females.

methodsA prospective nested 1:1 matched case-control study of CHD was conducted among participants in the Nurses' Health Study II (NHSII) and Health Professionals Follow-up Study (HPFS). Plasma concentrations of LBP and sCD14 were measured in 496 HPFS male CHD case-control pairs and 212 NHSII female pairs.

resultsAmong controls, plasma concentrations of LBP exhibited positive correlations with age, body mass index, and C-reactive protein (CRP) concentrations and an inverse correlation with high-density lipoprotein cholesterol concentrations. For sCD14, positive correlations with age and CRP were only observed in HPFS controls. Neither elevated LBP nor sCD14 concentrations were significantly associated with incident CHD in HPFS. In NHSII, higher sCD14 concentrations, but not LBP, were significantly associated with higher risk of CHD, with a risk ratio of 3.01 [95% confidence interval (CI): 1.28, 7.11] when comparing extreme quintiles. Collectively, CRP and the total cholesterol/ high-density lipoprotein cholesterol ratio explained 27.9% (95% CI: 7.1%, 66.1%; P = 0.01) of the positive association between sCD14 and CHD in NHSII females. These associations were not modified by physical activity, alcohol intake, body mass index, inflammation markers, family history of CHD, or the presence of hypertension, hyperlipidemia, or type-2 diabetes.

conclusionHigher concentrations of sCD14 may be associated with an increased risk of CHD in females, whereas LBP concentrations are not associated with CHD in either sex. These data do not support that LPS exposure in initially healthy individuals is a contributing CHD risk factor, although the potential sex difference should be explored further.

Indexed as

Carrier ProteinsCoronary DiseaseGastrointestinal MicrobiomeMembrane GlycoproteinsAcute-Phase ProteinsAdultAgedBiomarkersCase-Control StudiesC-Reactive ProteinFemaleHumansInflammationLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsMaleAcute-Phase ProteinsBiomarkersCarrier ProteinsC-Reactive ProteinLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsMembrane Glycoproteinscoronary heart diseaseepidemiologygut microbiotametabolitesprospective study

Identifiers

PMID41015192
PMCPMC13507946

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