ArticleCell reports2025
IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.
Abstract read
In one paragraph
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- IGF2BP3-mediated regulation of the RNA isoform and modification landscape in pancreatic cancer.Oncogene · 2026Article
- Article
- Targeting RNA-Binding Oncofetal Protein IGF2BP3: Discovery of Potent and Selective Inhibitors.Journal of medicinal chemistry · 2026Article
- Targeting IGF2BP3 in Cancer: From Molecular Structure and Biology to Early Drug Discovery.International journal of molecular sciences · 2026Review
- IGF2BP3 promotes glycolysis of osteosarcoma stem cells by reading RNA m⁶A to stabilize ENO1 and promote malignant biological behavior of osteosarcoma.Cell biology and toxicology · 2026Article
- LL22NC03-N14H11.1 regulates the m6A modification of MYC and promotes glycolytic activity in hepatocellular carcinoma cells by inhibiting IGF2BP3 ubiquitination degradation.Journal of experimental & clinical cancer research : CR · 2025Article
- IGF2BP3 remodels the microRNA targeting landscape in MLL-AF4 leukemia.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
22 authors.
Gunjan SharmaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Martin GutierrezDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA, USA.
Anthony E JonesDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Shruti KapoorDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA, USA.
Amit Kumar JaiswalDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Zachary T NeebDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA, USA.
Amy RiosDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Poornima DorairajDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Michelle L ThaxtonDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Tasha L LinDivision of Hematology and Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Tiffany M TranDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Lyna E S KabbaniDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA, USA.
Alexander J RitterDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA, USA.
Georgia M SchererDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Jacob P SorrentinoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Linsey StilesDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Johanna Ten HoeveDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Metabolomics Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Robert D DamoiseauxDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Neil K GargDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Ajit S DivakaruniDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Jeremy R SanfordDepartment of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA, USA; Center for Biomolecular Science & Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.
Dinesh S RaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA; Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: drao@mednet.ucla.edu.
Funding
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5MVirology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZACK, JEROME A. · 1991 to 2018
$39.9MNational Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7MProtein-RNA interactions in cancerR01CA264986 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Dinesh S. Rao, Jeremy Robert Sanford · 2021 to 2026
$3.7MBiomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2MRegulation of mRNA FateR35GM130361 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Jeremy Robert Sanford · 2019 to 2026
$3.1MUnderstanding How Metabolic Cofactors Control Cell Function and FateR35GM138003 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Ajit Divakaruni · 2020 to 2026
$2.8MWeb Portal CoreU2CDK119889 · NIDDK · UNIVERSITY OF FLORIDA · PI CONLON, MICHAEL, GARRETT, TIMOTHY J · 2018 to 2021
$1.9MRegulation of mRNA isoform fateR01GM109146 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SANFORD, JEREMY ROBERT · 2014 to 2017
$1.2MA postdoctoral training program for impactful careers in stem cell biologyT32HD108079 · NICHD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Bin Chen, CAMILLA FORSBERG · 2022 to 2026
$1.1MPathogenetic roles of USO1 in leukemogenesisR03CA251845 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAO, DINESH S · 2021 to 2022
$156kNCI NIH HHS P30 CA016042NCI NIH HHS R01 CA264986NCI NIH HHS R03 CA251845NIAID NIH HHS P30 AI028697NICHD NIH HHS T32 HD108079NIDDK NIH HHS U2C DK119886NIDDK NIH HHS U2C DK119889NIGMS NIH HHS R01 GM109146NIGMS NIH HHS R35 GM130361NIGMS NIH HHS R35 GM138003NIH HHS OT2 OD030544
Abstract
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an oncofetal RNA-binding protein and a non-canonical reader of N6-methyladenosine (m
Indexed as
CarbonGlycolysisRNA-Binding ProteinsAdenosineCell Line, TumorHumansMethionine AdenosyltransferaseMethylationRNA, MessengerRNA MethylationS-AdenosylmethionineAdenosineCarbonIGF2BP3 protein, humanMethionine AdenosyltransferaseN-methyladenosineRNA-Binding ProteinsRNA, MessengerS-AdenosylmethionineB-acute lymphoblastic leukemiaCP: MetabolismepitranscriptomicsMLL-rearranged leukemiaRNA-binding protein
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.