Evidence map›Paper›PMID 41014576›Full record

ArticleCPT: pharmacometrics & systems pharmacology2025

PD-1-Cis IL-2R Agonism Determines the Predicted Pharmacological Dose Range for the Immunocytokine Eciskafusp Alfa (PD1-IL2v).

Lucy G Hutchinson, Thomas D Lewin, Laura Lauener, Meret Martin-Facklam, Merlind Muecke, Volker Teichgraeber, Laura Codarri Deak

Abstract read
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucy G HutchinsonRoche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.ORCID 0000-0002-3845-5460
Thomas D LewinRoche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Laura LauenerRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.
Meret Martin-FacklamRoche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Merlind MueckeRoche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Volker TeichgraeberRoche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Laura Codarri DeakRoche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Binding in cis-configuration to the PD-1 receptor (PD-1) and IL-2

Indexed as

Programmed Cell Death 1 ReceptorReceptors, Interleukin-2Recombinant Fusion ProteinsDose-Response Relationship, DrugHumansNeoplasmsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Interleukin-2Recombinant Fusion Proteins

Identifiers

PMID41014576
PMCPMC12706404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.