ArticleVeterinary research communications2025
Curcumin as a protective agent for goat sperm viability and DNA integrity against bisphenol A toxicity and cryopreservation stress.
Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Oxidative stress induced by environmental toxicants such as Bisphenol A (BPA) and cryopreservation significantly impairs sperm quality in goats, leading to reduced viability, motility, membrane integrity, and increased DNA fragmentation. This study aimed to evaluate the protective effects of curcumin, a natural polyphenolic antioxidant on goat sperm exposed to BPA and cryopreservation stress in vitro. Three experiments were conducted using semen collected from healthy adult goats. In Experiment 1, sperm samples were treated with 30 µM BPA to induce oxidative damage, followed by curcumin supplementation at 0, 5, 10, and 20 µM. In Experiment 2, freshly collected semen was cryopreserved in liquid nitrogen (- 196 °C) with the same curcumin concentrations added to the freezing extender. In Experiment 3, commercial frozen goat semen straws were thawed in media supplemented with curcumin at identical concentrations. Each treatment was replicated 12 times. BPA exposure significantly decreased overall motility and progressive motility compared to control. Treatment with 10 µM curcumin effectively restored sperm quality. In cryopreserved samples, 5 µM curcumin provided optimal protection. Similarly, in thawed commercial semen, 5 µM curcumin significantly improved sperm performance. These results demonstrate that curcumin at optimal concentrations effectively mitigates oxidative stress-induced damage to goat sperm, whether from BPA toxicity or cryopreservation. The dual role of curcumin during both freezing and thawing underscores its practical value as an antioxidant additive in semen preservation protocols. Its inclusion could enhance sperm quality, promote fertility outcomes, and support reproductive biotechnology applications in animal breeding programs.
Indexed as
Identifiers
41014447What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.