ArticleJournal of fluorescence2026
Microbial-Modified Organosilica-Based Dual-Mode Fluorescent Probe for Zn²⁺ and pH Sensing with Potential Application in Gut Immunity Modulation.
Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
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Abstract
Crohn's disease (CD) involves chronic intestinal inflammation, often accompanied by abnormal zinc ion (Zn²⁺) homeostasis. Herein, we developed a multifunctional nanoplatform-1-DASA-ATPMS@2@Rg3-that integrates ginsenoside Rg3 with a DASA-modified silica-based composite for ratiometric Zn²⁺ sensing and anti-inflammatory therapy. The nanocomposite exhibited a distinct ratiometric fluorescence response to Zn²⁺, with a strong linear correlation (R² = 0.9969) between the intensity ratio (I₅₀₀/I₆₇₂) and Zn²⁺ concentration over 0-200 µM, enabling accurate quantification. Time-resolved fluorescence and zeta potential analyses confirmed Zn²⁺-induced coordination and electrostatic interactions, contributing to signal amplification. Additionally, the pH-dependent optical properties further support its adaptability to inflamed gut environments. This dual-functional nanoplatform not only enables precise Zn²⁺ monitoring-a crucial marker in CD progression-but also offers therapeutic benefits via Rg3-mediated immunomodulation, presenting a promising strategy for real-time inflammation sensing and intervention in CD.
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