ArticleMolecular biology reports2025
Human leukocyte antigen (HLA)-G gene + 3142G > C variant (rs1063320) confers susceptibility to rheumatoid arthritis in Indian Bengali population.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGenetic predisposition is an important and fundamental determinant of susceptibility to rheumatoid arthritis (RA), a chronic autoimmune disease with joint deformity and disability. HLA-G plays an important role in the modulation of autoimmune disorders and inflammatory processes. The HLA-G + 3142G > C and 14 bp insertion/deletion variants have a controversial impact on pathogenesis of RA in various populations globally. The present study aimed to evaluate the possible association of HLA-G + 3142 G > C and 14-bp insertion/deletion variants with RA and to compare the concentration of soluble HLA-G in serum of RA patients and healthy controls. METHODOLOGY: Two thirty RA patients and two fifty healthy controls fulfilling the ACR-EULAR/2010 criteria were included in this study. Genotyping of HLA-G + 3142G > C and 14 bp insertion/deletion variants was performed using PCR-RFLP and PCR-SSP methods, respectively. The concentration of soluble HLA-G was quantified using sHLA-G sandwich ELISA kit. Chi-squared test and unpaired t-test were employed for the analysis of categorical and continuous data, respectively, using SPSS 27.0. Bonferroni corrected p value < 0.05 was considered as statistically significant.
resultsSignificant difference in the genotype frequencies of HLA-G + 3142G > C variant was observed between RA patients and controls under codominant (GG versus GC: p = 0.009, OR = 1.817), dominant (GG versus GC + CC, p = 0.033, OR = 1.618) and over dominant (GG + CC versus GC: p = 0.002, OR = 1.847) inheritance models. Further, sHLA-G level was significantly reduced in RA patients as compared to controls (21.37 ± 10.53 ng/ml versus 29.83 ± 14.97 ng/ml, p < 0.001).
conclusionThe findings of this study reveal an association between + 3142G > C variant of HLA-G gene and increased risk of RA in Indian Bengali population. Further, decreased sHLA-G concentration in RA patients in contrast to healthy controls indicates the dysregulation of immunoregulatory mechanism in RA. However, extensive study is warranted to evaluate the alteration of sHLA-G expression in response to therapy and autoantibody status of RA patients.
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