ArticleEuropean archives of psychiatry and clinical neuroscience2026
Interpersonal sensitivity as a central hub: a network analysis of childhood trauma and psychological symptoms in adolescents with major depressive disorder.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundChildhood trauma exhibits complex associations with adolescent mental health, however the interplay between specific trauma subtypes and psychological symptoms remains underexplored. This study employs network analysis to map symptom-trauma interactions, identify potential intervention targets, and explore gender differences in these interactions among adolescents with major depressive disorder (MDD).
methodsA total of 723 adolescents diagnosed with MDD were recruited from a psychiatric clinic in China. Psychological symptoms (SCL-90) and childhood trauma exposure (CTQ) were assessed. Regularized partial correlation networks (EBICglasso) were utilized to model interactions among 15 nodes (10 symptoms and 5 trauma types), compute centrality metrics, and test gender differences.
resultsThe results revealed that Interpersonal sensitivity (IPS) emerged as the most central node, demonstrating the highest expected influence (EI) (1.67), and formed the strongest edge with emotional abuse (weight = 0.41). A tightly coupled community linked emotional abuse/neglect, IPS, and depression. Moreover, IPS functioned as a bridge symptom, connecting trauma clusters to psychological symptoms (bridge strength = 0.98). Node invariance testing revealed significant gender differences in IPS, however, within their respective gender-specific networks, IPS demonstrated the highest strength and EI values in both males and females. Essentially, no obvious significant gender differences were observed in the network.
conclusionsThis pioneering network study of trauma-symptom associations in Chinese adolescents with MDD identifies IPS as a transdiagnostic factor through which childhood trauma is associated with mental health risks. The structural equivalence across genders suggests universal intervention targets during adolescence. Clinically, enhancing interpersonal skills in emotionally traumatized youth may disrupt pathogenic pathways to depression and other psychology symptoms.
Indexed as
Identifiers
41014346What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.