ArticleCurrent microbiology2025
Bacterial Pneumonia Alters the Respiratory Microbiota and Inflammatory Profile Via the Lung Microbiome-Immune Axis.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Lung Microbiome Diversity, Infection Dynamics, and Microbe-Mediated Cross-Protection.MicrobiologyOpen · 2026Review
- Predicting Multidrug-Resistant Pneumonia: An Interpretable Machine Learning Model Validated in US and Chinese Patient Cohorts.Infection and drug resistance · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Bacterial invasion of the lungs causes pneumonia, which poses a serious threat to public health. In the absence of pathogen identification, the misuse of antibacterial agents contributes to bacterial resistance. This study investigated changes in the respiratory microbiome and proinflammatory profiles in bronchoalveolar lavage fluid (BALF) from patients with bacterial pneumonia before and after treatment, compared with healthy controls. Leukocyte count, granulocyte count, and neutrophil percentage were significantly elevated in patients with bacterial pneumonia. Microbial species richness in the untreated pneumonia group (group A) was significantly lower than in the treated group (group B) and healthy controls (group C). Significant differences in α-diversity and β-diversity were observed across all three groups. Linear discriminant analysis effect size (LEfSe) identified 19 microbial biomarkers at the genus level. Levels of TNF-α and IL-6 in BALF and serum were significantly reduced in group A following treatment, as measured by ELISA. Correlation analysis revealed associations between proinflammatory cytokines and several genera, including P5D1_392, Chloroplast, Blautia, Flavonifractor, Terrisporobacter, [Ruminococcus]_gauvreauii_group, Anaerostipes, Ruminococcus, Parabacteroides, Ellin6055, and Clostridia_UCG-014. These findings suggest that bacterial pneumonia disrupts the respiratory microbiota and alters the inflammatory profile through the lung microbiome-immune axis, leading to immune dysregulation. This work provides a theoretical basis for targeted treatment strategies in bacterial pneumonia.
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