Evidence map›Paper›PMID 41014225›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Development of a 3D Human Colon Model Along with Bioelectronics for the Induction and Monitoring of Diseases.

Jorge Alfonso Tavares-Negrete, Sahar Najafikoshnoo, Anita Ghandehari, Mozhgan Keshavarz, Quinton Smith, Armand Ahmetaj, Steven Zanganeh, Rahim Esfandyarpour

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jorge Alfonso Tavares-NegreteDepartment of Biomedical Engineering, University of California, Irvine, CA, 92697, USA.ORCID https://orcid.org/0000-0001-7695-460X
Sahar NajafikoshnooHenry Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
Anita GhandehariHenry Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
Mozhgan KeshavarzSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, 92697, USA.
Quinton SmithSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, 92697, USA.
Armand AhmetajBioengineering Program, New York Institute of Technology, New York, NY, 11568, USA.
Steven ZanganehBioengineering Program, New York Institute of Technology, New York, NY, 11568, USA.
Rahim EsfandyarpourDepartment of Biomedical Engineering, University of California, Irvine, CA, 92697, USA.ORCID https://orcid.org/0000-0002-4528-3601

Funding

University of California, Irvine Miguel Velez Fellowship
6 · The paper itself

Abstract

Conventional in vitro and animal models do not reproduce the geometry, mechanics, or transport physics of the human colon, limiting their fidelity for disease studies and drug screening. A patient-derived, freeform reversible embedding of suspended hydrogels bioprinted three-dimensional (3D) in vivo mimicking human-colon model (3D-IVM-HC) is reported whose micro-computed tomography (CT) profile deviates by less than 4% from the original computed tomography template and spontaneously forms crypt-like invaginations with a median depth of 65 µm. The dual-layer gelatin methacrylate (GelMA)/alginate matrix matches native colonic stiffness (9-65 kPa) and sustains >95% cell viability with a 14-fold metabolic increase over 14 days. Caco-2 epithelia polarize within the lumen, form continuous Zonula occludens-1 (ZO-1) belts, and reach a transepithelial electrical resistance (TEER) of 68 ± 4 Ω cm

Indexed as

ColonModels, BiologicalCaco-2 CellsHumansHydrogelsPrinting, Three-DimensionalX-Ray MicrotomographyHydrogels3D colon human modelcolorectal cancer modelingin vivo mimickingnon‐animal model

Identifiers

PMID41014225
PMCPMC12677662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.