Evidence map›Paper›PMID 41014202›Full record

ArticleArchiv der Pharmazie2025

Loading of Dicarboxylatoplatinum(II)-NHC Complexes in Bacterial Ghosts as an Advanced Development in Cancer Therapy.

Amelie Scherfler, Klaus Wurst, Stefan Schwaiger, Francesco Baschieri, Martin Hermann, Daniel Baecker, Irena Pashkunova-Martic, Brigitte Kircher, Hristo P Varbanov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Current clinical applications and future developments of platinum-based anticancer drugs.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amelie ScherflerDepartment of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0009-0009-0054-524X
Klaus WurstDepartment of General, Inorganic, and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Stefan SchwaigerDepartment of Pharmacognosy, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-3731-7349
Francesco BaschieriInstitute of Pathophysiology, Medical University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0003-0218-5320
Martin HermannDepartment of Anesthesiology & Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Daniel BaeckerDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1963-9838
Irena Pashkunova-MarticDepartment of Biomedical Imaging and Image-Guided Therapy, Division of Structural and Molecular Preclinical Imaging, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-0312-6461
Brigitte KircherDepartment of Internal Medicine V, Haematology & Oncology, Immunobiology and Stem Cell Laboratory, Medical University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0003-1624-2664
Hristo P VarbanovDepartment of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0003-4450-7332

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

This study aimed to improve the drug-like properties of benzimidazole-based Pt(II)-N-heterocyclic carbene (NHC) complexes, particularly by enhancing their water solubility and delivery to cancer cells. Accordingly, four new Pt(II) complexes of the benzimidazol-2-ylidene type, featuring monodentate carboxylato ligands, were prepared and their structures confirmed through a combination of spectroscopic and crystallographic techniques. Their stability in aqueous solution and cell culture medium was investigated by

Indexed as

Antineoplastic AgentsEscherichia coliOrganoplatinum CompoundsApoptosisCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHumansMolecular StructureOvarian NeoplasmsStructure-Activity RelationshipAntineoplastic AgentsOrganoplatinum Compoundsbacterial ghostscytotoxicityNHC ligandsovarian cancerplatinum(II) complexes

Identifiers

PMID41014202
PMCPMC12476087

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.