Evidence map›Paper›PMID 41014158›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Near-Infrared Conjugated Macrocyclic BODIPYs for Photothermal Cancer Therapy.

Fei Cheng, Taotao Qiang, Mingli Li, Ruilong Li, Zhigao Wang, Tony D James

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Near-Infrared Conjugated Macrocyclic BODIPYs for Photothermal Cancer Therapy.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fei ChengCollege of Bioresources and Materials Engineering, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry & Technology, Shaanxi University of Science & Technology, Xi'an, 710021, China.ORCID 0009-0006-3720-3639
Taotao QiangCollege of Bioresources and Materials Engineering, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry & Technology, Shaanxi University of Science & Technology, Xi'an, 710021, China.ORCID 0000-0003-3505-2049
Mingli LiCollege of Bioresources and Materials Engineering, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry & Technology, Shaanxi University of Science & Technology, Xi'an, 710021, China.
Ruilong LiCollege of Bioresources and Materials Engineering, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry & Technology, Shaanxi University of Science & Technology, Xi'an, 710021, China.
Zhigao WangCollege of Pharmacy, Xi'an Medical University, Xi'an, 710021, China.
Tony D JamesDepartment of Chemistry, University of Bath, Bath, BA27AY, United Kingdoms.ORCID 0000-0002-4095-2191

Funding

National Natural Science Foundation of China 52273268Qin Chuang-yuan Team Construction Project of Shaanxi Science and Technology Department 2022KXJ-165School of Chemistry and Chemical Engineering, Henan Normal University 2020ZD01Shaanxi Province Outstanding Youth Science Foundation Project 2025JC-JCQN-053Shaanxi Province Technology Innovation Guidance Project 2023GXLH-079
6 · The paper itself

Abstract

With this research we developed a cyclization strategy that effectively converts radiative transitions (RTs) to non-radiative transitions (NRTs) during the decay process of BODIPY-based photosensitizers. Compared to BODIPY monomers, cyclization leads to a significant decrease in the HOMO-LUMO energy gap and a significant increase in the HOMO energy. In particular, the absorption spectrum of 7a exhibits a significant redshift, with the maximum absorption wavelength reaching 794 nm. Photophysical characterization indicates that the macrocyclic BODIPY derivatives 7(a-d) exhibit a reduced RT process. While, the crystal structure and theoretical calculations suggest that the molecular ring distortion enhances the intersystem crossing (ISC) ability of the macrocyclic BODIPY derivatives 7(a-d). In addition 7a-NPs constructed using DSPE-mPEG

Indexed as

Antineoplastic AgentsBoron CompoundsMacrocyclic CompoundsNeoplasmsPhotosensitizing AgentsPhotothermal TherapyAnimalsCell SurvivalHumansInfrared RaysMiceMolecular Structure4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAntineoplastic AgentsBoron CompoundsMacrocyclic CompoundsPhotosensitizing AgentsNon‐radiative transitionPhotothermal conversion efficiencyPhotothermal therapyRadiative transition

Identifiers

PMID41014158
PMCPMC12624305

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.