ArticleBritish journal of clinical pharmacology2026
Prescription use of acetaminophen among pregnant women in Denmark from 2000 to 2023: A drug utilization study.
Article in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Prescription use of acetaminophen among pregnant women in Denmark from 2000 to 2023: A drug utilization study.British journal of clinical pharmacology · 2026Article
- Paracetamol exposure during pregnancy, the risk of major congenital malformations, and perinatal and postnatal outcomes: a population-based cohort study.Human reproduction open · 2026Article
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5 authors.
Funding
Abstract
aimsThe aim of this study was to describe prescription use of acetaminophen, a widely used analgesic and antipyretic generally considered safe during pregnancy, among pregnant women from 2000 to 2023 in Denmark with special attention towards variations following the change in over-the-counter (OTC) availability in 2013.
methodsIn this population-based drug utilization study, individually linked data from nationwide health registries on pregnant women in Denmark between 2000 and 2023 were used to evaluate time trends on prescription use of acetaminophen and describe distributions of maternal characteristics among prescription-based drug users and non-users.
resultsAmong 1 446 841 eligible pregnancies included, 27 per 1000 pregnant women redeemed at least one prescription for acetaminophen during pregnancy, and among these, 18% redeemed more than one. In 2023, 74 per 1000 pregnancies were exposed to prescription use of acetaminophen. Relative to non-users, prescription-based drug users were generally older and had a higher body mass index. They more frequently presented with pain-related, chronic or psychiatric conditions and used other prescription medications throughout the study period. However, these differences were less pronounced in the cohort restricted to pregnancies ending in 2015-2023 compared to 2000-2012.
conclusionsPrescription use of acetaminophen in the pregnant population in Denmark has increased since 2000, with a notable sharp increase from 2013 onwards, coinciding with the regulatory restriction that reduced over-the-counter pack sizes, alongside a concurrent rise in general-population prescription use. Prescription-based drug users were more likely to have comorbidities and multiple medication use than non-users, although these differences have become less pronounced in recent years.
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