ArticleThe clinical respiratory journal2025
Evaluation of PD-L1 Expression in Patients With Non-Small Cell Lung Cancer Using DCE-MRI Quantitative Analysis.
Article in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Evaluation of PD-L1 Expression in Patients With Non-Small Cell Lung Cancer Using DCE-MRI Quantitative Analysis.The clinical respiratory journal · 2025Article
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6 authors.
Funding
Abstract
purposeThe aim is to evaluate the expression of programmed death ligand 1 (PD-L1) in patients with non-small cell lung cancer (NSCLC) using quantitative perfusion parameters based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
methodsA total of 35 patients with a confirmed diagnosis of NSCLC and sufficient tissue pathology were enrolled in the study. The immunohistochemical (IHC) results were used as the gold standard to determine the thresholds for grouping the patients. The patients were divided into three categories based on their PD-L1 expression: (1) PD-L1-negative (IHC < 1%) and PD-L1-positive (IHC ≥ 1%); (2) PD-L1 weak (IHC < 50%) and strong expression (IHC ≥ 50%); and (3) PD-L1 nonexpression (IHC < 1%), low expression (IHC between 1% and 49%), and high expression (IHC ≥ 50%). DCE-MRI datasets were analyzed to acquire histogram parameters, including mean value, uniformity, skewness, kurtosis, entropy, energy, and quantity, of quantitative perfusion parameters using the extended Tofts model (ETM) and the exchange model (ECM). Subsequently, the parameters were compared between the aforementioned groups.
resultsIHC showed PD-L1 < 1% in 20 cases, PD-L1 (1%-49%) in 14 cases, and PD-L1 ≥ 50% in 14 cases. At a threshold of 50%, statistically significant differences were observed for ETM/K
conclusionDCE-MRI quantitative analysis is a valuable tool for the evaluation of PD-L1 expression in NSCLC. It provides a noninvasive method that can be employed as an adjunctive technique for the stratification of PD-L1 expression in patients with NSCLC.
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