ReviewInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2025
The epidemiology and pathogenesis of uterine fibroids.
Review in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- From prevalence to precision: Integrating phenotype, symptoms, reproductive goals, and treatment in leiomyoma care.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Fumarate Hydratase-Deficient Uterine Leiomyomas: Germline Genetic Findings and Clinical Follow-Up in a Single-Center Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Transradial access in interventional gynecology and obstetrics: Current evidence, clinical applications, and future directions.European journal of obstetrics & gynecology and reproductive biology: X · 2026Review
- A Comparative Analysis of the Methylation Status of Non-Coding RNA Promoters in Fibroid and Matched Myometrium.International journal of molecular sciences · 2026Article
- Optimization of Newly Diagnosed Hypertension and Type II Diabetes Mellitus Before Myomectomy for Symptomatic Uterine Leiomyoma.Clinical case reports · 2026Article
- In vivo inhibition of TDO2 in fibroids results in widespread alteration in the tumor transcriptome.Clinical science (London, England : 1979) · 2026Article
- Endometrial Dysfunction in Women with Ovarian and Uterine Tumors: What Is Known and What Should Be Learned?International journal of molecular sciences · 2026Review
- Integrated genetic and clinical investigation of autosomal dominant hereditary uterine leiomyomas: genotype-phenotype correlation in a pakistani family.Molecular biology reports · 2026Article
- Article
- Preclinical research platform for uterine leiomyoma: construction optimization and selection of animal models.Frontiers in veterinary science · 2026Article
- Burden and Trends of Six Gynecological Diseases Among Chinese Women Aged 15-49 Years, 1990-2021: Evidence from GBD 2021.International journal of women's health · 2026Article
- Diagnosis and classification of uterine fibroids.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uterine fibroids, or leiomyomas, are the most common benign tumors of the female reproductive tract, ultimately affecting a majority of women worldwide, primarily during their reproductive years. While their origin appears genetic, manifesting in monoclonal tumors, diverse features and mechanisms contribute to their growth and further development. Understanding the interplay between epidemiological and biological factors is vital for clinicians and essential for investigators, whether basic, translational, clinical, or epidemiological, who aim to shed light on this ubiquitous clinical problem. Leiomyomas are experienced globally, and while there are relatively minor differences in the lifetime prevalence for women, the tumors appear to develop in those of African ancestry earlier than white women. While most leiomyomas are not symptomatic, those that cause symptoms can adversely affect lifestyle, physical function, and fertility and exert substantial socioeconomic pressure on healthcare systems. Because most leiomyomas are asymptomatic, it is also apparent that, in many cases, presenting symptoms may not be caused by the tumors themselves. As a result, it is essential that the clinician understand the pathogenesis of these tumors and how they manifest with symptoms. Despite their prevalence and evolving understanding of genetic, racial, and environmental factors contributing to their growth and development, much remains to be learned about these ubiquitous tumors in a way that can inform strategies for prevention, early detection, and effective therapy. This paper reviews the current understanding of the epidemiology and pathogenesis of uterine fibroids, highlighting key risk factors, genetic and molecular mechanisms, and implications for public health.
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