Evidence map›Paper›PMID 41013958›Full record

ReviewAdvanced healthcare materials2026

Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses.

Asmasadat Vaziri, Renata Maia, Pei Zhang, Liliana Agresti, Jelmer Sjollema, Mohammad-Ali Shahbazi, Hélder A Santos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Biomaterials in organoid research: current state and future directions.Frontiers in bioengineering and biotechnology · 2026
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Asmasadat VaziriDepartment of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, AV Groningen, 9713, The Netherlands.
Renata MaiaDepartment of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, AV Groningen, 9713, The Netherlands.
Pei ZhangDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, 00014, Finland.
Liliana AgrestiDepartment of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, AV Groningen, 9713, The Netherlands.
Jelmer SjollemaDepartment of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, AV Groningen, 9713, The Netherlands.
Mohammad-Ali ShahbaziDepartment of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, AV Groningen, 9713, The Netherlands.
Hélder A SantosDepartment of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, AV Groningen, 9713, The Netherlands.ORCID 0000-0001-7850-6309

Funding

H2020 Marie Skłodowska-Curie Actions 101007804Nederlandse Organisatie voor Wetenschappelijk Onderzoek 1292.19.354
6 · The paper itself

Abstract

Over the past decade, granular hydrogels have been widely utilized as a cell-free or cell-laden platform to deliver therapeutics (e.g., cells and drugs) for tissue repair, or as a bioink or supporting bed for bioprinting. Owing to their inherent microporosity and modularity, various granular hydrogels with functional applications for in vivo use have been fabricated to enhance cell infiltration, spreading and migration, harness immune response, and promote tissue regeneration. In this review, an updated overview of the current state-of-the-art is provided for granular hydrogel development, by highlighting the interplay between design parameters and structural characteristics, like porosity, microstructure, rheological behavior, injectability, and degradability, and their influence on biological responses in various biomedical engineering applications.

Indexed as

Biocompatible MaterialsHydrogelsAnimalsHumansPorosityTissue EngineeringBiocompatible MaterialsHydrogelsbiomedical engineeringgranular hydrogelInter/intraparticle crosslinkingmicroparticlesmicroporous

Identifiers

PMID41013958
PMCPMC12817117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.