Evidence map›Paper›PMID 41013897›Full record

ReviewPlant communications2025

Transport of secondary metabolites in plants: Mechanistic insights and transporter engineering for crop improvement.

Chunsheng Xiao, Gaofeng Zhou, Tianhua He, Chengdao Li

Abstract readReview
In one paragraph

Review in Plant communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chunsheng XiaoWestern Crop Genetic Alliance, Murdoch University, Perth, WA 6150, Australia; State Agricultural Biotechnology Centre (SABC), College of Science, Health, Engineering and Education, Murdoch University, Perth, WA 6150, Australia.
Gaofeng ZhouWestern Crop Genetic Alliance, Murdoch University, Perth, WA 6150, Australia.
Tianhua HeWestern Crop Genetic Alliance, Murdoch University, Perth, WA 6150, Australia.
Chengdao LiWestern Crop Genetic Alliance, Murdoch University, Perth, WA 6150, Australia; State Agricultural Biotechnology Centre (SABC), College of Science, Health, Engineering and Education, Murdoch University, Perth, WA 6150, Australia; Department of Primary Industry and Regional Development, Government of Western Australia, South Perth, WA 6155, Australia. Electronic address: c.li@murdoch.edu.au.

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Secondary metabolites (SMs) are essential for plant survival and adaptation, playing multiple roles in ecological interactions such as defense and stress tolerance. Specialized transporters relocate SMs from their synthesis sites to defense tissues or storage organs. The spatiotemporal distribution of defense-related SMs is a key determinant of plant fitness. However, the accumulation of anti-nutritional SMs in crop seeds or fruits can pose health risks to humans and livestock. Recent advances have revealed the critical role of SM transporters in optimizing metabolite allocation. This review examines the transport mechanisms of both defense and anti-nutritional SMs, with a particular focus on long-distance transporters that regulate source-sink dynamics and their potential applications in agricultural biotechnology. We highlight innovative strategies to manipulate transporter activity, ranging from multi-omics integration to precision engineering, and discuss how these approaches can be used to design crops with enhanced defense capacity, increased levels of beneficial compounds, and improved palatability of seeds and fruits. Finally, we outline emerging technologies and conceptual frameworks for discovering and characterizing long-distance SM transporters for crop improvement. Transporter-focused strategies offer promising solutions to global agricultural challenges and provide new opportunities for advancing crop improvement in the context of global food security.

Indexed as

Crops, AgriculturalMembrane Transport ProteinsPlant ProteinsSecondary MetabolismBiological TransportMembrane Transport ProteinsPlant Proteinscrop improvementgenetic manipulationlong-distance transportsecondary metabolitestransporters

Identifiers

PMID41013897
PMCPMC12744758

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.