Evidence map›Paper›PMID 41013875›Full record

ReviewNeurogastroenterology and motility2025

Fibers and Polyphenols in Diverticular Disease: From Pathophysiology to Management.

Claudia Marinaccio, Annamaria Altomare, Benedetto Neri, Laura Restaneo, Dario Biasutto, Simone Carotti, Michele Cicala, Chiara Fanali, Michele Pier Luca Guarino

Abstract readReview
In one paragraph

Review in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claudia MarinaccioResearch Unit of Gastroenterology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Roma, Italy.
Annamaria AltomareResearch Unit of Gastroenterology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Roma, Italy.ORCID https://orcid.org/0000-0001-8630-7836
Benedetto NeriTherapeutic GI Endoscopy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Laura RestaneoDepartment of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Roma, Italy.
Dario BiasuttoDepartment of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Roma, Italy.
Simone CarottiMicroscopic and Ultrastructural Anatomy Research Unit, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Michele CicalaResearch Unit of Gastroenterology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Roma, Italy.
Chiara FanaliResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Roma, Italy.
Michele Pier Luca GuarinoResearch Unit of Gastroenterology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Roma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsDiverticular disease, particularly symptomatic uncomplicated diverticular disease (SUDD), significantly impacts patient quality of life and is increasing in prevalence, especially in Western countries. While its pathophysiology is multifactorial, diet-specifically low fiber intake-has been implicated as a key modifiable factor in disease development and progression. Fibers influence colonic motility and stool composition, potentially reducing the formation of diverticula and symptom severity. Polyphenols, bioactive compounds with antioxidant and anti-inflammatory properties, may further protect intestinal integrity and modulate gut microbiota. PURPOSE: This narrative review explores emerging evidence on the role of dietary fiber and polyphenols in SUDD management. Despite promising mechanistic insights, current studies are limited by heterogeneity and methodological constraints. Personalized nutritional strategies focusing on fiber and polyphenol-rich foods warrant further investigation to optimize therapeutic outcomes in SUDD.

Indexed as

Dietary FiberDiverticular DiseasesPolyphenolsGastrointestinal MicrobiomeHumansDietary FiberPolyphenolsdietary fiberdiverticular diseasegut microbiotaintestinal inflammationnutritional therapypolyphenols

Identifiers

PMID41013875
PMCPMC12623275

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.