ArticleEuropean journal of medical research2025
Exploring the effect of capsaicin on gene expression and chemotherapy sensitization in gastric cancer cells.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Immunometabolic and immune regulatory functions of capsaicin in cancer: mechanistic insights and emerging perspectives.Frontiers in immunology · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundCapsaicin, phytochemical component in red hot chili peppers, has previously been demonstrated to exhibit antitumor effect in various cancer type. However, the deep biological function and molecular mechanism of capsaicin was still uncertain.
methodsThis study applied cell viability assay, apoptosis assay, Transwell assay, immunofluorescence, qPCR, western blot assay and high-throughput RNA sequencing to explore the effect of capsaicin on gene expression and chemotherapy sensitization in gastric cancer cells.
resultsCapsaicin could significantly inhibit cell viability and induce apoptosis in both AGS and HGC-27 gastric cancer cell line. Through high-throughput RNA sequencing, capsaicin exhibited inhibiting role in DNA repair, DNA replication and chromosome assemble pathway. qPCR assay and western blot validated that capsaicin could inhibit expression of the key enzymes (FEN1, LIG1 and PARP1) in DNA damage response and chemotherapy resistance. In vitro assay demonstrated that capsaicin could significantly induce cyto-toxicity and chemotherapy-induced DNA damage of 5-FU and Oxalipatin at low dose. Immunofluorescence analysis revealed that capsaicin inhibited both the expression and nuclear accumulation of PARP1 in AGS cells treated with 5-FU or oxaliplatin.
conclusionsCapsaicin could inhibit DNA repair, thereby inhibited cell viability and improved the sensitivity of chemotherapy in gastric cancer cells.
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