Evidence map›Paper›PMID 41013783›Full record

ArticleCell & bioscience2025

A novel self-inhaled nicotine exposure system in murine models reveals age-dependent metabolic effects of nicotine.

Xu Xu, Hailan Liu, Meng Yu, Qingzhuo Liu, Yongxiang Li, Yue Deng, Yuxue Yang, Jingjing Cheng, Yutian Liu, Mengjie Wang and 19 more

Abstract read
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In one paragraph

Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Xu XuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Hailan LiuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Meng YuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Qingzhuo LiuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Yongxiang LiDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Yue DengDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Yuxue YangDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Jingjing ChengDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Yutian LiuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Mengjie WangDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Xing FangDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Longlong TuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Olivia Z GinnardDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Kristine M McDermottDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Darah ThreatDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Fuhui WangDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Meixin SunDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Xinming LiuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Jiamin QiuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Xi WuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Jinjing JianDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Tong ZhouDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Megan E BurtDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Sanika V JossyDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Junying HanDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Chunmei WangDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Yongjie YangDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA.
Yong XuDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA. yongx@bcm.edu.ORCID http://orcid.org/0000-0002-4908-1572
Yuhan ShiDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, 1100 Bates Street #8066, Houston, TX, 77030, USA. yuhan.shi@bcm.edu.ORCID http://orcid.org/0009-0006-2460-0889

Funding

A CHOLINERGIC NEUROCIRCUIT REGULATES FEEDING BEHAVIORR01DK138518 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, YONG XU · 2024 to 2026
$1.9M
ESTROGEN-INDUCIBLE PNNS ENHANCE EXCITATORY SYNAPTIC STRENGTH ONTO GABA NEURONS IN THE MEPD TO PREVENT OBESITY AND METABOLIC DYSREGULATIONR01DK136627 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Chunmei Wang · 2023 to 2026
$1.8M
PERIFORNICAL AREA OF THE ANTERIOR HYPOTHALAMUS REGULATES METABOLIC BALANCEF32DK138685 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Xing Fang · 2024 to 2026
$257k
5-HT NEURONS AND MEAL REGULATIONF32DK134121 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI MCDERMOTT, KRISTINE MARIE · 2023 to 2025
$225k
Agricultural Research Service 3092- 51000-062-04(B)SAgricultural Research Service 51000-064-01SAmerican Heart Association 23POST1030352NIDDK NIH HHS DK136627NIDDK NIH HHS F32 DK134121NIDDK NIH HHS F32DK134121NIDDK NIH HHS F32 DK138685NIDDK NIH HHS F32DK138685NIDDK NIH HHS R01 DK136627NIDDK NIH HHS R01 DK138518NIDDK NIH HHS R01DK138518
6 · The paper itself

Abstract

backgroundNicotine is known to influence metabolism and body weight, yet existing murine models of nicotine exposure often fail to replicate human smoking behaviors accurately. To address this gap, we designed a cost-effective, self-administered nicotine inhalation system that allows mice to voluntarily inhale nicotine vapor generated from e-liquid.

resultsUsing this system, we investigated the metabolic effects of nicotine exposure in adult and adolescent mice. Adult mice exposed to nicotine vapor for 10 days exhibited significant weight loss, which was rapidly regained upon cessation, paralleling human smoking patterns. In contrast, adolescent mice did not lose weight during nicotine exposure but experienced increased fat mass accumulation after cessation. These results highlight critical age-dependent differences in nicotine's metabolic effects and challenge the common perception that nicotine aids in weight control among adolescents.

conclusionsOur novel e-liquid-based inhalation model provides a valuable tool for studying nicotine's physiological and behavioral effects, with implications for understanding smoking-related health risks and addiction mechanisms.

Indexed as

Age-dependent metabolic effectsSelf-inhaled nicotine

Identifiers

PMID41013783
PMCPMC12465302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.