ArticleEuropean journal of medical research2025
Early laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage in acute cholecystitis is appropriate and safe: an inverse probability of treatment weighting analysis.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Outcomes of acute moderate cholecystitis management techniques: percutaneous transhepatic gallbladder drainage and early laparoscopic cholecystectomy.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Surgical Complications in Conventional and Laparoscopic Cholecystectomy in an Ecuadorian Reference Hospital.Cureus · 2026Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute cholecystitis (AC) is a common emergency requiring timely surgical intervention. While laparoscopic cholecystectomy (LC) is the standard treatment, the optimal timing for LC following percutaneous transhepatic gallbladder drainage (PTGBD) remains debated. This study evaluates and compares the safety and efficacy of early LC after PTGBD, immediate LC without PTGBD, and delayed LC following PTGBD.
methodsA retrospective cohort study was conducted at a Level I referral center, analyzing 1436 patients diagnosed with AC and managed surgically between 2010 and 2018. Patients were categorized into three groups: early LC after PTGBD (Early group, n = 18), immediate LC without PTGBD (Immediate group, n = 1243), and delayed LC following PTGBD (Delayed group, n = 175). Patient demographics, clinical characteristics, and surgical outcomes were analyzed using inverse probability of treatment weighting (IPTW) to adjust for baseline differences.
resultsCompared to the Immediate group, the Early group had a higher proportion of older patients and multiple comorbidities. After adjustment, adverse event rates were similar between both groups, but major complications were lower in the Early group. Compared to the Delayed group, the Early group demonstrated significantly shorter hospital stays and lower major complication rates.
conclusionsEarly LC after PTGBD during the same admission is a viable alternative to delayed LC, reducing hospital stay and complications. Immediate LC remains the preferred approach for eligible patients without prior PTGBD. Further prospective studies are needed to refine the optimal timing of LC following PTGBD.
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