Evidence map›Paper›PMID 41013717›Full record

SynthesisStem cell research & therapy2025

Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of extracellular vesicles and conditioned media.

Alireza Jafarzadeh, Seyed Soheil Hoseini, Elham Behrangi, Masoumeh Roohaninasab, Azadeh Goodarzi

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alireza JafarzadehDepartment of Dermatology, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Asadabadi Street, 21st Street, Next to Shafaq Park, Tehran, 1445613131, Iran.ORCID http://orcid.org/0000-0001-5878-9778
Seyed Soheil HoseiniFaculty of Medicine, Iran University of Medical Sciences, Shahid Hemmat Highway, Tehran, 1449614535, Iran.ORCID http://orcid.org/0009-0001-0155-7439
Elham BehrangiDepartment of Dermatology, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Asadabadi Street, 21st Street, Next to Shafaq Park, Tehran, 1445613131, Iran.ORCID http://orcid.org/0000-0002-6545-3460
Masoumeh RoohaninasabDepartment of Dermatology, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Asadabadi Street, 21st Street, Next to Shafaq Park, Tehran, 1445613131, Iran.ORCID http://orcid.org/0000-0002-2862-6422
Azadeh GoodarziDepartment of Dermatology, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Asadabadi Street, 21st Street, Next to Shafaq Park, Tehran, 1445613131, Iran. azadeh_goodarzi1984@yahoo.com.ORCID http://orcid.org/0000-0002-1249-4429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS AND

objectivesThis study aims to evaluate and summarize the efficacy and safety of extracellular vesicles (EVs) and conditioned media (CM) as emerging therapeutic approaches in regenerative medicine for skin rejuvenation and lightening.

methodsA systematic search was conducted up to September 19, 2024, using the PubMed, Scopus, and Web of Science databases. Keywords included "conditioned media," "secretome," "extracellular vesicles," "exosome," "rejuvenation," "lightening," and others. Studies were screened based on predefined inclusion criteria, followed by data extraction. Key extracted data included study design, population characteristics (mean age and range), intervention duration, comparisons, outcomes with statistical results, and adverse effects. The statistical methods applied in individual studies were documented to assess the validity of reported improvements.

resultsThis review included 19 studies with a total of 624 patients evaluating the efficacy and safety of EVs and CMs for skin lightening and rejuvenation. Among these, 21% investigated the effects of EVs, while 78% focused on CMs. The most commonly assessed skin parameters included wrinkles, pigmentation, spots, elasticity, and hydration. Various application methods were used, including topical administration, microneedling, and fractional laser therapy. Reported improvements included a 27.07% increase in skin elasticity (p < 0.05), over 10% reduction in wrinkles (p < 0.05), and more than 20% enhancement in hydration (p < 0.05). No serious adverse effects were reported, with only transient minor reactions such as erythema observed.

conclusionEVs and CMs appear to be safe and potentially effective for skin rejuvenation and lightening. However, further high-quality studies are required to confirm long-term safety, investigate variations in efficacy based on cell sources, and optimize application techniques for clinical use.

Indexed as

Extracellular VesiclesRegenerative MedicineRejuvenationSkin AgingCulture Media, ConditionedHumansSkinCulture Media, ConditionedConditioned mediaConditioned mediumEVExosomeExtracellular vesiclesLighteningRegenerative medicineRejuvenationSecretomeSystematic review

Identifiers

PMID41013717
PMCPMC12465346

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.