Evidence map›Paper›PMID 41013695›Full record

ArticleJournal of nanobiotechnology2025

Neutrophil membrane-encapsulated nanosonosensitizer with ultrasound-reinforced ferroptosis in Pseudomonas aeruginosa pneumonia.

Chunhong Du, Shuai Wang, Yijie Cheng, Jie Li, Yufei Zhang, Zhuohao Li, Baolin Zhu, Zhongming Wu, Xinge Zhang, Lingyi Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chunhong Du *Department of Blood Transfusion, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Shuai Wang *Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
Yijie ChengKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Jie LiKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Yufei ZhangKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Zhuohao LiKey Laboratory of Advanced Energy Materials Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Baolin ZhuKey Laboratory of Advanced Energy Materials Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China. zhubaolin@nankai.edu.cn.
Zhongming WuDepartment of Endocrinology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, 250021, Shandong, China. wuzhongming@sph.com.cn.
Xinge ZhangKey Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China. zhangxinge@nankai.edu.cn.
Lingyi ZhouDepartment of Blood Transfusion, Tianjin Medical University General Hospital, Tianjin, 300052, China. tjdwzz0321@tmu.edu.cn.

Funding

Xinge Zhang 22475108Zhongming Wu 82370844
6 · The paper itself

Abstract

Pneumonia caused by Pseudomonas aeruginosa (P. aeruginosa) infection remains a formidable clinical challenge due to persistent biofilm formation and intrinsic antibiotic resistance, exacerbated by bacterial iron homeostasis that stabilizes biofilm architecture and neutralizes oxidative stress. Herein, we present Fe/TNT@NM, a biomimetic nanosonosensitizer activated by ultrasound (US) to dismantle biofilms through dual extracellular-intracellular mechanisms. The nanosonosensitizer features an iron-doped titanate nanotube (Fe/TNT) core encapsulated within a neutrophil membrane (NM). Under US irradiation, Fe/TNT@NM generates sonodynamic reactive oxygen species (ROS) extracellularly and enhances Fe

Indexed as

FerroptosisNeutrophilsPneumoniaPseudomonas aeruginosaPseudomonas InfectionsAnimalsAnti-Bacterial AgentsBiofilmsCell MembraneHumansIronMiceNanotubesReactive Oxygen SpeciesUltrasonic WavesAnti-Bacterial AgentsIronReactive Oxygen SpeciesBacterial ferroptosisChemodynamic therapyNeutrophils membraneP. aeruginosa pneumoniaSonodynamic therapy

Identifiers

PMID41013695
PMCPMC12465798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.