ReviewCardiovascular diabetology. Endocrinology reports2025
The effects of diabetes on the glymphatic system: recent advances and mechanistic insights.
Review in Cardiovascular diabetology. Endocrinology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- Glymphatic system impairment in type II diabetes mellitus adults.Scientific reports · 2026Article
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Authors and funding
1 author.
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Abstract
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and is associated with a variety of systemic complications, including cardiovascular diseases, neuropathies, and cognitive decline. An emerging area of interest is the impact of diabetes on the glymphatic system, a waste clearance system in the central nervous system (CNS) that plays a critical role in maintaining brain homeostasis. Recent studies suggest that glymphatic dysfunction may contribute to the pathogenesis of diabetic encephalopathy, a condition characterized by cognitive deficits and an increased risk of neurodegenerative diseases such as Alzheimer's disease (AD). This review provides a review of the effects of diabetes on the glymphatic system, drawing on a broad spectrum of recent research. We examine the mechanistic underpinnings of glymphatic impairment in diabetes, the role of hyperglycemia and insulin resistance, and the potential therapeutic implications. We also explore the broader context of diabetes-related CNS changes, including the impact on cerebrovascular function, neuroinflammation, and sleep disturbances. Finally, we discuss future directions in this rapidly evolving field, highlighting the need for further research into the glymphatic system as a therapeutic target in diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.