Evidence map›Paper›PMID 41013659›Full record

ArticleAntimicrobial resistance and infection control2025

Etiology and antimicrobial resistance patterns of sepsis in infants 0-59 days old in Jimma, Ethiopia: a longitudinal study.

Daniele Gusland, Melkamu Berhane, Mekdes Shimekit, Mulatu Gashaw, Alemseged Abdissa, Jens C Eickhoff, Dawd S Siraj, James H Conway

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniele GuslandDepartment of Pediatrics, Division of Infectious Diseases, University of Wisconsin-Madison, Madison, USA.
Melkamu BerhaneDepartment of Pediatrics and Child Health, Jimma University, Jimma, Ethiopia. melkamuarefayine@gmail.com.
Mekdes ShimekitDepartment of Pediatrics and Child Health, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia.
Mulatu GashawSchool of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia.
Alemseged AbdissaSchool of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia.
Jens C EickhoffDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, USA.
Dawd S SirajDepartment of Medicine, Division of Infectious Diseases, University of Wisconsin-Madison, Madison, USA.
James H ConwayDepartment of Pediatrics, Division of Infectious Diseases, University of Wisconsin-Madison, Madison, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn Ethiopia, empiric treatment for sepsis or possible serious bacterial infection (PSBI) in infants 0-59 days old is based on World Health Organization (WHO) guidelines. We aimed to assess the etiology, antimicrobial susceptibility and outcomes of empiric treatment in PSBI in Jimma, Ethiopia and created local antibiograms to assess empiric treatment guidelines in this setting.

methodsWe prospectively enrolled 363 infants 0-59 days of age admitted to Jimma University Hospital with PSBI over 12-months. Following institutional practice, blood and cerebrospinal fluid (CSF) cultures were collected; positive cultures were identified and evaluated for antibiotic susceptibility. We compared microbiologic results to the WHO guideline based empiric treatment selections at the hospital and evaluated the clinical outcomes at discharge and 30-days of age.

resultsOf 279 patients who had blood cultures obtained, 212(76.0%) were positive, yielding 216 isolates. Four CSF cultures were positive and were included in analysis of blood cultures due to the smaller number of isolates. The most common isolates were Klebsiella (31.8%), coagulase-negative Staphylococci (24.6%), and Staphylococcus aureus (11.6%). Of Klebsiella species, 87% were resistant to at least one commonly utilized antibiotic and 82% were resistant to first-line empiric antimicrobials. In-hospital mortality was 12.3% and it was highest (41%) in participants with Klebsiella. At 30-days of age, mortality for infants with positive culture was 6.6%.

conclusionsIsolates from PSBI showed high rates of antibiotic resistance to first- and second-line antimicrobials. In this setting, the WHO empiric treatment guidelines inadequately treat infants admitted with PSBI, particularly those with Klebsiella. To provide the most effective care for PSBI in 0-59 days old infants, institutionally used guidelines should be customized to reflect local epidemiology and resistance patterns.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialSepsisEthiopiaFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleMicrobial Sensitivity TestsProspective StudiesStaphylococcus aureusAnti-Bacterial AgentsAntimicrobial resistanceInfantsNeonatesOutcomePossible serious bacterial infectionsSepsis

Identifiers

PMID41013659
PMCPMC12465210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.