Evidence map›Paper›PMID 41013649›Full record

ArticleNutrition journal2025

Association between relative fat mass and obstructive sleep apnea and the potential mediating effect of hypertension: based on NHANES 2005-2008 and 2015-2018.

Qizheng Guo, Weihang Xu, Changcong Wang, Muchen Xie, Zhuoxin Wu, Ning Zhang, Baorui Zhang, Dongmei Mu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qizheng GuoSchool of Public Health, Jilin University, Changchun, China.ORCID http://orcid.org/0009-0009-4395-844X
Weihang XuSchool of Public Health, Jilin University, Changchun, China.ORCID http://orcid.org/0000-0003-3005-9612
Changcong WangSchool of Public Health, Jilin University, Changchun, China.ORCID http://orcid.org/0000-0003-1354-9345
Muchen XieSchool of Public Health, Jilin University, Changchun, China.ORCID http://orcid.org/0009-0005-1354-9742
Zhuoxin WuSchool of Public Health, Jilin University, Changchun, China.ORCID http://orcid.org/0009-0008-3772-0550
Ning ZhangSchool of Public Health, Jilin University, Changchun, China.ORCID http://orcid.org/0009-0004-6595-5892
Baorui ZhangSchool of Public Health, Jilin University, Changchun, China.ORCID http://orcid.org/0009-0004-9052-6889
Dongmei MuSchool of Public Health, Jilin University, Changchun, China. moudm@jlu.edu.cn.ORCID http://orcid.org/0000-0003-1457-303X

Funding

National Natural Science Foundation of China,China 72374081Science and Technology Development Plan of Jilin Province YDZJ202301ZYTS001
6 · The paper itself

Abstract

backgroundObesity has been identified as one of the contributing factors to obstructive sleep apnea (OSA). The current obesity assessment indicators have poor ability to distinguish between fat and muscle. Relative fat mass (RFM) a new indicator of obesity that takes into account gender differences and can predict body fat conditions has advantage in this respect. This study aimed to investigate the potential association between RFM and OSA, as well as the possible mediating effect of hypertension.

methodsThis cross-sectional study used data from the National Health and Nutrition Examination Survey conducted in 2005-2008 and 2015-2018. Multivariate logistic regression, restricted cubic splines (RCS), and subgroup analyses were performed to evaluate the association between RFM and OSA. In addition, the receiver operating characteristic curve (ROC) of different obesity indicators was compared to assess their predictive ability for OSA. Mediation analysis was used to explore the potential mediating role of hypertension in the positive correlation.

resultsThe study included 13,532 participants with complete study data, of which 6854 were assessed as having OSA according to the criteria, accounting for 50.65% of the study population. The results of the multivariate logistic regression model with fully adjusted covariates showed that the odds ratio of RFM was 1.096 (95%CI:1.084-1.109, P < 0.001). The results of the RCS show that RFM is nonlinearly correlated with OSA (P for nonlinear < 0.01). Subgroup analysis showed that the association between RFM and OSA was stronger in female and people younger than 60. The ROC also indicates that, compared with the body roundness index and weight-adjusted-waist index, RFM showed potential as a predictor. Mediation analysis and sensitivity analysis showed that hypertension had a statistically significant but poorly robust mediating effect between RFM and OSA.

conclusionThere is a positive and nonlinear correlation between RFM and OSA. Hypertension plays a potential mediating role in the positive association between RFM and OSA, but its robustness is poor. RFM shows potential as a predictor of OSA, but more prospective studies are needed to confirm these findings and determine the causal relationship between RFM and OSA.

Indexed as

Adipose TissueHypertensionObesitySleep Apnea, ObstructiveAdultAgedBody Mass IndexCross-Sectional StudiesFemaleHumansLogistic ModelsMaleMiddle AgedNutrition SurveysRisk FactorsROC CurveHypertensionNHANESObesityObstructive sleep apneaRelative fat mass

Identifiers

PMID41013649
PMCPMC12465428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.